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CAS No.: | 77174-66-4 |
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Name: | Croconazole hydrochloride |
Molecular Structure: | |
Formula: | C18H15 Cl N2 O . Cl H |
Molecular Weight: | 347.244 |
Synonyms: | 1H-Imidazole,1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]ethenyl]-, monohydrochloride (9CI);710674S;Croconazole hydrochloride;Croconazole monohydrochloride;Pilzcin; |
Melting Point: | 148.5-150° |
Safety: | Moderately toxic by ingestion, skin contact, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx. |
PSA: | 27.05000 |
LogP: | 5.43650 |
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Product Name: Croconazole hydrochloride (CAS NO.77174-66-4)
Molecular Formula: C18H16Cl2N2O
Molecular Weight: 347.23844g/mol
Mol File: 77174-66-4.mol
Boiling point: 501.5 °C at 760 mmHg
Flash Point: 257.1 °C
Density: 1.16 g/cm3
Surface Tension: 41.7 dyne/cm
Enthalpy of Vaporization: 77.03 kJ/mol
Vapour Pressure: 3.45E-10 mmHg at 25°C
H-Bond Donor: 1
H-Bond Acceptor: 2
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 94mg/kg (94mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984. |
mouse | LD50 | oral | 1150mg/kg (1150mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984. |
mouse | LD50 | subcutaneous | 1gm/kg (1000mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984. |
rabbit | LD | skin | > 320mg/kg (320mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4847, 1984. | |
rabbit | LDLo | subcutaneous | 1715mg/kg (1715mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4821, 1984. |
rat | LD50 | intraperitoneal | 204mg/kg (204mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984. |
rat | LD50 | oral | 2gm/kg (2000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984. |
rat | LD50 | skin | > 600mg/kg (600mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984. | |
rat | LD50 | subcutaneous | 4700mg/kg (4700mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984. |
Moderately toxic by ingestion, skin contact, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx.
Croconazole hydrochloride ,its CAS NO. is 77174-66-4,the synonyms is 1-[1-[2-[(3-Chlorophenyl)methoxy]phenyl]ethenyl]imidazole hydrochloride ; Cloconazole hcl ; Croconazolehcl ; Cloconazol clorhidrato .