Products Categories
| CAS No.: | 78919-13-8 |
|---|---|
| Name: | ILOPROST |
| Article Data: | 10 |
| Molecular Structure: | |
|
|
|
| Formula: | C22H32O4 |
| Molecular Weight: | 360.494 |
| Synonyms: | Ataprost [INN]; Ataprostum; Iloprost; 5-{(E)-(1S,5S,6R,7R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-bicyclo[3.3.0]octa-3-ylidene)-pentanoic acid; 5-{(E)-(1S,5S,6R,7R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-5-octen-6-inyl]-bicyclo[3.3.0]-octan-3-ylidene}pentenoic acid; Ataprostum [INN-Latin]; Pentanoic acid,5-(4-(3-cyclopentyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2(1H)-pentalenylidene)-,(3aS-(2E,3aalpha,4alpha(1E,3R*),5beta,6aalpha)); Ataprost; 查看更多英文别名 收起 |
| Density: | 1.21g/cm3 |
| Melting Point: | 115.7oC |
| Boiling Point: | 539.2oC at 760 mmHg |
| Flash Point: | 294oC |
| Appearance: | colorless oil |
| PSA: | 77.76000 |
| LogP: | 3.54130 |
- 81281-59-67-Benzylideneaminotheophylline
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 90221-55-92-bromo-5-methylbenzaldehyde
- 885590-99-82,3-DIFLUORO-4-IODOBENZALDEHYDE
- 97730-31-9(S)-4'-(2-Methylbutyl)Biphenyl-4-Carbonitrile
What can I do for you?
Get Best Price
Specification
This chemical is called Iloprost [INN:BAN], and its systematic name is Pentanoic acid, 5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)-. With the product categories of Antianginal Drugs; Cardiovascular Drugs, its classification codes are Cardiovascular Agents; Drug / Therapeutic Agent; Hematologic Agents; Platelet Reproductive Effect; Treatment of pulmonary hypertension [prostacyclin analogue]; Vasodilator agents. The CAS registry number of this chemical is 78919-13-8. Additionally, it should be stored at -20°C.
Other characteristics of the Iloprost [INN:BAN] can be summarised as followings: (1)XLogP3-AA: 2.8; (2)H-Bond Donor: 3; (3)H-Bond Acceptor: 4; (4)Rotatable Bond Count: 8; (5)Exact Mass: 360.23006; (6)MonoIsotopic Mass: 360.23006; (7)Topological Polar Surface Area: 77.8; (8)Heavy Atom Count: 26; (9)Formal Charge: 0; (10)Complexity: 606; (11)Isotope Atom Count: 0; (12)Defined Atom StereoCenter Count: 4; (13)Undefined Atom StereoCenter Count: 2; (14)Defined Bond StereoCenter Count: 2; (15)Undefined Bond StereoCenter Count: 0; (16)Covalently-Bonded Unit Count: 1; (17)Feature 3D Acceptor Count: 4; (18)Feature 3D Donor Count: 2; (19)Feature 3D Anion Count: 1; (20)Feature 3D Hydrophobe Count: 3; (21)Feature 3D Ring Count: 2; (22)Effective Rotor Count: 9; (23)Conformer Sampling RMSD: 1.2; (24)CID Conformer Count: 275.
Synthesis of this chemcial: The Iloprost [INN:BAN] could be obtained by compound I.
.jpg)
Uses of this chemical: This chemical is an eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. Its actions are similar to prostacyclin. The Iloprost [INN:BAN] produces vasodilation and inhibits platelet aggregation. It's used for angina, atherosclerosis.
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 201mg/kg (201mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | New Cardiovascular Drugs. Vol. 4, Pg. 209, 1986. |
| mouse | LD50 | oral | > 100mg/kg (100mg/kg) | Drugs of the Future. Vol. 6, Pg. 676, 1981. | |
| rat | LD50 | intravenous | 119mg/kg (119mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | New Cardiovascular Drugs. Vol. 4, Pg. 209, 1986. |
| rat | LD50 | oral | > 100mg/kg (100mg/kg) | Drugs of the Future. Vol. 6, Pg. 676, 1981. |