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CAS No.: | 80370-57-6 |
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Name: | Ceftiofur |
Article Data: | 6 |
Molecular Structure: | |
Formula: | C19H17N5O7S3 |
Molecular Weight: | 523.571 |
Synonyms: | 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-,[6R-[6a,7b(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-,(6R,7R)- (9CI);CM 31916;Excede;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-,(6R,7R)-; |
EINECS: | 1308068-626-2 |
Density: | 1.81 g/cm3 |
Appearance: | White to off-white powder |
Safety: | 24/25 |
PSA: | 256.26000 |
LogP: | 1.89100 |
1. Introduction of Ceftiofur
Ceftiofur is one kind of white powder. Besides, the IUPAC Name of it is (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(furan-2-carbonylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. In addition, it belongs to APIs;cephalosporins antibiotics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds. The Classification Code of it is Anti-Bacterial Agents; Anti-Infective Agents; Antibacterial [veterinary]. It was first described in 1987.
2. Properties of Ceftiofur
Physical properties about Ceftiofur are:
(1)Melting Point: 190-200°C; (2)Product Categories: APIs; cephalosporins antibiotics; (3)H bond acceptors: 12; (4)H bond donors: 4; (5)Freely Rotating Bonds: 9; (6)Polar Surface Area: 213.69 Å2; (7)Index of Refraction: 1.819; (8)Molar Refractivity: 125.23 cm3; (9)Molar Volume: 287.7 cm3; (10)Surface Tension: 86.2 dyne/cm; (11)Density of Ceftiofur: 1.81 g/cm3.
3. Structure Descriptors of Ceftiofur
(1)InChI: InChI=1S/C19H17N5O7S3/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28)/b23-11-/t12-,16-/m1/s1
(2)InChIKey: InChIKey=ZBHXIWJRIFEVQY-IHMPYVIRSA-N
(3)Smiles: o1cccc1C(SCC1=C(N2[C@H](SC1)[C@@H](NC(=O)C(\c1nc(sc1)N)=N\OC)C2=O)C(=O)O)=O
4. Uses of Ceftiofur
Ceftiofur (CAS NO.80370-57-6) is an antibiotic of the cephalosporin type.It is use in veterinary medicine. In addition, it is licensed for use in veterinary medicine. It is resistant to the antibiotic resistance enzyme beta-lactamase, and has activity against Gram-positive and Gram-negative bacteria. E. coli strains resistant to ceftiofur have been reported.