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| CAS No.: | 804-36-4 |
|---|---|
| Name: | Difurazone |
| Molecular Structure: | |
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| Formula: | C14H12 N6 O6 |
| Molecular Weight: | 360.286 |
| Synonyms: | Guanidine,[[3-(5-nitro-2-furyl)-1-[2-(5-nitro-2-furyl)vinyl]allylidene]amino]-(6CI,7CI,8CI); Hydrazinecarboximidamide,2-[3-(5-nitro-2-furanyl)-1-[2-(5-nitro-2-furanyl)ethenyl]-2-propenylidene]-(9CI); 1,4-Pentadien-3-one, 1,5-bis(5-nitro-2-furanyl)-,(aminoiminomethyl)hydrazone; 1,5-Bis(5-nitro-2-furyl)-3-pentadienoneamidinohydrazone; Biovin 40; Bis(5-nitro-2-furfurylidene)acetoneguanylhydrazone; Bis(5-nitrofurfurylidine)acetone guanylhydrazone; Difurazone;Nitrovin |
| EINECS: | 212-358-7 |
| Density: | 1.59g/cm3 |
| Melting Point: | 217° (dec) |
| Boiling Point: | 575.8oC at 760 mmHg |
| Flash Point: | 302.1oC |
| Safety: | Poison by intraperitoneal route. Moderately toxic by subcutaneous route. Mildly toxic by ingestion. Questionable carcinogen. A growth promoter in chickens. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx. |
| PSA: | 192.18000 |
| LogP: | 4.49200 |
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Chemistry
Molecular Formula: C14H12N6O6
Molecular Weight: 360.28
EINECS: 212-358-7
Density: 1.58 g/cm3
Appearance: 217°C
Flash Point: 313.4 °C
Index of Refraction: 1.679
Enthalpy of Vaporization: 88.63 kJ/mol
Boiling Point: 594.6 °C at 760 mmHg
Vapour Pressure: 4.15E-14 mmHg at 25°C
Appearance: Dark purple crystallization
IUPAC Name: 2-[[(1E,4E)-1,5-bis(5-nitrofuran-2-yl)penta-1,4-dien-3-ylidene]amino]guanidine
Solubility: Soluble in ethanol, dimethyl sulfoxide, DMF, pyridine and other organic solvent, hardly soluble in water and ethyl ether
Synonyms: Nitrovin ; ((3-(5-Nitro-2-furyl)-1-(2-(5-nitro-2-furyl)vinyl)allylidene)amino)guanidine ; 1,5-Bis(5-nitro-2-furanyl)-1,4-pentadien-3-one,(aminoiminomethyl)hydrazone ; 1,5-Bis(5-nitro-2-furyl)-3-pentadienoneamidinonhydrazone ; 1,5-Bis(5-nitro-2-furyl)-3-pentadienoneguanylhydrazone ; Bis(5-nitrofurfurylidene)acetoneguanylhydrazone ; Sym-bis(5-nitro-2-furfurylidene)acetoneguanylhydrazone ; 1-(3-(5-Nitro-2-furyl)-1-(2-(5-nitro-2-furyl)vinyl)allylideneamino)guanidine hydrochloride
Following is the molecular structure of Panazone (804-36-4):
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Uses
Panazone (804-36-4) as livestock growth promoters, promote growth and improve the feed conversion drought. After many years, the state has good application effect of proof. In this 20ppm mix feeding, pigs started from broken, can increase until listing 7 percent, feed conversion rate and improve the health of pig meat flavour, carcass, no influence. For the lamb, and the meat but also promote the growth of the role. Rats oral LD50 > 10 g/kg, mice to 6.4 g/kg. This product is not in gastrointestinal absorption, few organizations.
Production
Panazone (804-36-4) is formed by 5 - nitro furfural in zinc with acetone, carbonic acid amine TMG condensation. Yield can reach more than 50%.
Toxicity Data With Reference
| 1. | mmo-sat 2500 ng/L | CEHYAN Ceskoslovenska Hygiena. Czechoslovak Hygiene. 32 (1987),276. | ||
| 2. | orl-mus LD50:5330 mg/kg | PMDCAY Progress in Medical Chemistry. 5 (1967),320. | ||
| 3. | ipr-mus LD50:300 mg/kg | PMDCAY Progress in Medical Chemistry. 5 (1967),320. | ||
| 4. | scu-mus LD50:3750 mg/kg | PMDCAY Progress in Medical Chemistry. 5 (1967),320. |
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 117.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 31 ,1983,p. 185.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .
Safety Profile
Poison by intraperitoneal route. Moderately toxic by subcutaneous route. Mildly toxic by ingestion. Questionable carcinogen. A growth promoter in chickens. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx.