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8059-24-3

Basic Information
CAS No.: 8059-24-3
Name: Vitamin B6
Molecular Structure:
Molecular Structure of 8059-24-3 (Vitamin B6)
Formula: C10H16N2O3S
Molecular Weight: 231.14200
Synonyms: Adermine;Vitamin B6(Pyridoxine Hydrochloride);Pyridoxine HCL(Vitamin B6);
EINECS: 232-503-8
Melting Point: 231-233oC(lit.)
Boiling Point: 567.6oC at 760 mmHg
Flash Point: 297.1oC
Appearance: powder
Safety: 24/25
PSA: 115.35000
LogP: 1.88970
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    CAS No.: 65-23-6 Other Names: Pyridoxine HCL MF: C8H11NO3 EINECS No.: 200-399-3 Place of Origin: China (Mainland) Type: Vitamins, Amino Acids and Coenzymes

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    Product Name: Vitamin B6 CAS: 8059-24-3 MF: C10H16N2O3S MW: 244.31 EINECS: 232-503-8 Product Categories: Mol File: 8059-24-3.mol Vitamin B6 Structure Vitamin B6 Chemical Properties Melting point 231-233 °C(lit.) storage

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Chemistry

Molecular Structure:

Molecular Formula: C10H16N2O3S
Molecular Weight: 244.3106
IUPAC Name: (5-Hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate
Synonyms of Vitamin B6 (CAS NO.8059-24-3): Adermine ; EINECS 232-503-8 ; Vitamin H
CAS NO: 8059-24-3
Classification Code: Growth Substances ; Micronutrients ; Vitamin B Complex ; Vitamins
Melting point: 231-233 °C
Index of Refraction: 1.544
Molar Refractivity: 60.88 cm3
Molar Volume: 192.7 cm3
Surface Tension: 45.9 dyne/cm
Density: 1.267 g/cm3
Flash Point: 300.7 °C
Enthalpy of Vaporization: 93.93 kJ/mol
Boiling Point: 573.6 °C at 760 mmHg
Vapour Pressure: 1.19E-14 mmHg at 25°C 

History

  Vitamin B6 (CAS NO.8059-24-3) is a water-soluble compound that was discovered in the 1930s during nutrition studies on rats. In 1934, a Hungarian physician, Paul Gyorgy discovered a substance that was able to cure a skin disease in rats (dermititis acrodynia), this substance he named vitamin B6. In 1938, Lepkovsky isolated vitamin B6 from rice bran. Harris and Folkers in 1939 determined the structure of pyridoxine, and, in 1945, Snell was able to show that there are two forms of vitamin B6, pyridoxal and pyridoxamine. Vitamin B6 was named pyridoxine to indicate its structural homology to pyridine. All three forms of vitamin B6 are precursors of an activated compound known as pyridoxal 5'-phosphate (PLP), which plays a vital role as the cofactor of a large number of essential enzymes in the human body.
Enzymes dependent on PLP focus a wide variety of chemical reactions mainly involving amino acids. The reactions carried out by the PLP-dependent enzymes that act on amino acids include transfer of the amino group, decarboxylation, racemization, and beta- or gamma-elimination or replacement. Such versatility arises from the ability of PLP to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates.
Overall, the Enzyme Commission has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities.
The effectiveness as treatment for PMS, PMDD, and clinical depression is debatable.B6 is also considered an experimental but potentially effective treatment for schizophrenia and autism.

Uses

  Vitamin B6 (CAS NO.8059-24-3) has long been publicized as a cure for premenstrual syndrome (PMS). Study results conflict as to which symptoms are eased, but most of the studies confirm that women who take B6 supplements have reductions in bloating, breast pain, and premenstrual acne flare, a condition in which pimples break out about a week before a woman's period begins.There is strong evidence that pyridoxine supplementation, starting ten days before the menstrual period, prevents most pimples from forming. This effect is due to the vitamin's role in hormone and prostaglandin regulation. Skin blemishes are typically caused by a hormone imbalance, which vitamin B6 helps to regulate.
Mental depression is another condition which may result from low vitamin B6 intake. Because of pyridoxine's role in serotonin and other neurotransmitter production, supplementation often helps depressed people feel better, and their mood improves significantly. It may also help improve memory in older adults.
It is also suggested that ingestion of vitamin B6 can alleviate some of the many symptoms of an alcoholic hangover and morning sickness from pregnancy. This might be due to B6's mild diuretic effect.Though the mechanism is not known, results show that pyridoxamine has a therapeutic effects in clinical trials for diabetic nephropathy.
 

Safety Profile

Safety Statements of Vitamin B6 (CAS NO.8059-24-3): 24/25 
S24/25: Avoid contact with skin and eyes.
WGK Germany: 1
RTECS: XJ9088200
F: 8