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CAS No.: | 84-97-9 |
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Name: | 10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine |
Article Data: | 15 |
Molecular Structure: | |
Formula: | C20H25 N3 S |
Molecular Weight: | 339.505 |
Synonyms: | Phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]- (6CI,7CI,8CI);10-(3-Methylpiperazinopropyl)phenothiazine; 10-(g-Methylpiperazinopropyl)phenothiazine;10-[3-(1-Methylpiperazin-4-yl)propyl]phenothiazine;10-[3-(4-Methyl-1-piperazinyl)propyl]phenothiazine;10-[3-(4-Methylpiperazinyl)propyl]phenothiazine; NSC 638694; P 725; Perazine;Pernazine; Psytomin; Taxilan |
Density: | 1.149g/cm3 |
Melting Point: | 51-53oC |
Boiling Point: | 493.6°C at 760 mmHg |
Flash Point: | 252.3°C |
Safety: | Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human toxic effects by unspecified route. When heated to decomposition it emits very toxic fumes of NOx and SOx. |
PSA: | 35.02000 |
LogP: | 3.86760 |
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Chemistry informtion about Pernazine (CAS NO.84-97-9) is:
IUPAC Name: 10-[3-(4-Methylpiperazin-1-Yl)Propyl]Phenothiazine
Synonyms: 10-[3-(4-Methyl-1-Piperazinyl)Propyl]-10h-Phenothiazine ; Perazine ; 10-[3-[4-Methyl-1-Piperazinyl] Propyl] Phenothiazine ; 10h-Phenothiazine, 10-(3-(4-Methyl-1-Piperazinyl)Propyl)-, (Z)-2-Buten Edioate (1:2) ; 10-[3-(4-Methylpiperazinyl)Propyl]Phenothiazine ; Nsc 638694 ; P 725 ; Pernazine
Product Categories: Heterocyclic Compounds ; Heterocycles ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Sulfur & Selenium Compounds
MF: C20H25N3S
MW: 339.4976
EINECS: 201-578-9
Density: 1.149 g/cm3
Melting Point: 51-53°C
Flash Point: 252.3 °C
Boiling Point: 493.6 °C at 760 mmHg
Vapour Pressure: 6.91E-10 mmHg at 25°C
Enthalpy of Vaporization: 76.08 kJ/mol
Following is the molecular structure of Pernazine (CAS NO.84-97-9) is:
Pernazine (CAS NO.84-97-9) was used as Antipsychotic.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
human | TDLo | unreported | 270mg/kg/28D (270mg/kg) | behavioral: somnolence (general depressed activity) behavioral: ataxia | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 911, 1982. |
mouse | LD50 | intraperitoneal | 185mg/kg (185mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
mouse | LD50 | intravenous | 75mg/kg (75mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
mouse | LD50 | oral | 640mg/kg (640mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
mouse | LD50 | subcutaneous | 560mg/kg (560mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
rabbit | LD50 | intravenous | 25mg/kg (25mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
rat | LD50 | intraperitoneal | 300mg/kg (300mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
rat | LD50 | intravenous | 80mg/kg (80mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
rat | LD50 | oral | 500mg/kg (500mg/kg) | behavioral: convulsions or effect on seizure threshold | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 1, 1958. |
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human toxic effects by unspecified route. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Pernazine (CAS NO.84-97-9) is a crystalline solid.