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Basic Information
| CAS No.: | 86-34-0 |
|---|---|
| Name: | PHENSUXIMIDE |
| Molecular Structure: | |
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| Formula: | C11H11 N O2 |
| Molecular Weight: | 189.214 |
| Synonyms: | Succinimide,N-methyl-2-phenyl- (6CI,7CI,8CI); (?à)-Phensuximide; 1-Methyl-3-phenyl-2,5-pyrrolidinedione; 1-Methyl-3-phenylsuccinimide;Epimid; Lifene; Milontin; Milonton; Mirontin; N-Methyl-2-phenylsuccinimide;N-Methyl-3-phenylpyrrolidinedione; N-Methyl-3-phenylsuccinimide; N-Methyl-a-phenylsuccinimide; PM 334;Phensuximid; Phensuximide; RS-Phensuximide; Racemic phensuximide; Succitimal |
| Density: | 1.1596 (rough estimate) |
| Melting Point: | 71-73° |
| Boiling Point: | 324.47°C (rough estimate) |
| Solubility: | 4.2g/L(25 oC) |
| Safety: | Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human mutation data reported. An anticonvulsant. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 37.38000 |
| LogP: | 1.09680 |
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PHENSUXIMIDE
Chemistry
Synonyms: 1-methyl-3-phenyl-5-pyrrolidinedione;1-Methyl-3-phenylpyrrolidin-2,5-dione;Epimid;Fenosuccimide；1-Methyl-3-Phenylsuccinimide; 1-Methyl-3-phenyl-2,5-pyrrolidinedione;
MF: C11H11NO2
MW: 189.21
EINECS: 201-664-6
Uses
The main effect is used to cure Epilepsy seizures, applicable to small effect than three pairs of ketone which is low toxicity.
Toxicity Data With Reference
| 1. | cyt-hmn:leu 100 µg/L | AJOGAH American Journal of Obstetrics and Gynecology. 116 (1973),867. | ||
| 2. | orl-mus LD50:700 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 23 (1973),377. | ||
| 3. | ipr-mus LD50:402 mg/kg | EJMCA5 European Journal of Medicinal Chemistry. Chimie Therapeutique. 13 (1978),465. |
Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human mutation data reported. An anticonvulsant. When heated to decomposition it emits toxic fumes of NOx.