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Basic Information
CAS No.: 86-34-0
Name: PHENSUXIMIDE
Article Data: 27
Molecular Structure:
Molecular Structure of 86-34-0 (PHENSUXIMIDE)
Formula: C11H11 N O2
Molecular Weight: 189.214
Synonyms: Succinimide,N-methyl-2-phenyl- (6CI,7CI,8CI); (?à)-Phensuximide; 1-Methyl-3-phenyl-2,5-pyrrolidinedione; 1-Methyl-3-phenylsuccinimide;Epimid; Lifene; Milontin; Milonton; Mirontin; N-Methyl-2-phenylsuccinimide;N-Methyl-3-phenylpyrrolidinedione; N-Methyl-3-phenylsuccinimide; N-Methyl-a-phenylsuccinimide; PM 334;Phensuximid; Phensuximide; RS-Phensuximide; Racemic phensuximide; Succitimal
Density: 1.1596 (rough estimate)
Melting Point: 71-73°
Boiling Point: 324.47°C (rough estimate)
Solubility: 4.2g/L(25 oC)
Safety: Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human mutation data reported. An anticonvulsant. When heated to decomposition it emits toxic fumes of NOx.
PSA: 37.38000
LogP: 1.09680
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Chemistry

Synonyms: 1-methyl-3-phenyl-5-pyrrolidinedione;1-Methyl-3-phenylpyrrolidin-2,5-dione;Epimid;Fenosuccimide；1-Methyl-3-Phenylsuccinimide; 1-Methyl-3-phenyl-2,5-pyrrolidinedione;
MF: C11H11NO2
MW: 189.21
EINECS: 201-664-6

 

Uses

The  main effect is used to cure Epilepsy seizures, applicable to small effect than three pairs of ketone which is low toxicity.

Toxicity Data With Reference

1.   

cyt-hmn:leu 100 µg/L

   AJOGAH    American Journal of Obstetrics and Gynecology. 116 (1973),867.
2.   

orl-mus LD50:700 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 23 (1973),377.
3.   

ipr-mus LD50:402 mg/kg

   EJMCA5    European Journal of Medicinal Chemistry. Chimie Therapeutique. 13 (1978),465.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human mutation data reported. An anticonvulsant. When heated to decomposition it emits toxic fumes of NOx.