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| CAS No.: | 86-54-4 |
|---|---|
| Name: | Hydralazine |
| Molecular Structure: | |
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| Formula: | C8H8 N4 |
| Molecular Weight: | 160.178 |
| Synonyms: | 1(2H)-Phthalazinone,hydrazone (9CI); Phthalazine, 1-hydrazino- (6CI,8CI); 1-Hydrazinophthalazine;1-Phthalazinylhydrazine; Apresolin; Apresoline; Apressin; Apressin(pharmaceutical); Aprezolin; Ba 5968; C 5968; Ciba 5968; Hidralazin;Hipoftalin; Hydralazin; Hydralazine; Hypophthalin; NSC 126699 |
| EINECS: | 201-680-3 |
| Density: | 1.2583 (rough estimate) |
| Melting Point: | 172 ºC |
| Boiling Point: | 276.07°C (rough estimate) |
| Solubility: | 4.8mg/L(22.5 oC) |
| Appearance: | Yellow needles from methanol. |
| Safety: | Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: allergic dermatitis, cardiomyopathy, changes in coronary arteries. Human teratogenic effects by an unspecified route: developmental abnormalities of the blood and lymphatic system. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 63.83000 |
| LogP: | 1.68870 |
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Chemistry
IUPAC Name: Phthalazin-1-ylhydrazine
Product Name: Hydralazine
The MF of Hydralazine (CAS NO.86-54-4) is C8H8N4.
The MW of Hydralazine (CAS NO.86-54-4) is 160.17592.
Synonyms of Hydralazine (CAS NO.86-54-4): 1(2H)-Phthalazinone, hydrazone, (1Z)- ; 1-Hydrazinophthalazine ; Phthalazin-1-yl-hydrazine ; [2H-Phthalazin-(1Z)-Ylidene]-Hydrazine Hydrochloride ; (2H)-Phthalazinone, hydrazone, monohydrochloride ; (2H)-Phthalazinone, hydrazone ; 1-Phthalazinylhydrazine
Product Categories: Amines;Aromatics;Heterocycles;Inhibitors
Apperance: Yiellow Solid
Index of Refraction: 1.777
EINECS: 201-680-3
Density: 1.373 g/ml
Flash Point: 251.3 °C
Boiling Point: 491.9 °C
Melting Point: 172 °C
Uses
Hydralazine (CAS NO.86-54-4) inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression.Used as Non-selective MAO-A/B inhibitor, semicarbazide-sensitive amine oxidase inhibitor and antihypertensive.
Production
Preparation Products: Hyaluronidase
Toxicity Data With Reference
| 1. | mma-sat 500 µg/plate | MUREAV Mutation Research. 66 (1979),247. | ||
| 2. | slt-dmg-unr 200 mmol/L/6H | MUREAV Mutation Research. 120 (1983),233. | ||
| 3. | orl-man TDLo:2086 mg/kg/2Y-I:SKN | BMJOAE British Medical Journal. 289 (1984),410. | ||
| 4. | orl-wmn TDLo:730 mg/kg/2Y-I:SKN | BMJOAE British Medical Journal. 289 (1984),410. | ||
| 5. | ims-man TDLo:89 µg/kg:CVS | EJPEDT European Journal of Pediatrics. 145 (1986),318. | ||
| 6. | orl-rat LD50:90 mg/kg | PLRCAT Pharmacological Research Communications. 8 (1976),295. | ||
| 7. | ipr-rat LD50:25 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 143 (1964),7. | ||
| 8. | ivn-rat LD50:34 mg/kg | JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 40 (1951),559. | ||
| 9. | orl-mus LD50:122 mg/kg | PLRCAT Pharmacological Research Communications. 8 (1976),295. | ||
| 10. | ipr-mus LD50:100 mg/kg | JMCMAR Journal of Medicinal Chemistry. 22 (1979),671. | ||
| 11. |
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 222.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 , 1980,p. 85.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .
Safety Profile
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: allergic dermatitis, cardiomyopathy, changes in coronary arteries. Human teratogenic effects by an unspecified route: developmental abnormalities of the blood and lymphatic system. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.