CAS No.89226-75-5,Manidipine hydrochloride Suppliers

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Basic Information

Molecular Structure:
CAS No.:	89226-75-5
Name:	Manidipine hydrochloride
Article Data:	8

Formula:	C₃₅H₃₈N₄O₆^.2HCl
Molecular Weight:	683.632
Synonyms:	3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI);CV4093;Calslot;Franidipine hydrochloride;
EINECS:	680-304-3
Melting Point:	157-163°; mp 174-180°; mp 167-170°
Boiling Point:	722 °C at 760 mmHg
Flash Point:	390.4 °C
Solubility:	Soluble in DMSO. Slightly soluble in water and ethanol /n
PSA:	116.93000
LogP:	6.48280

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Chemistry

Molecular Formula: C₃₅H₄₀Cl₂N₄O₆
Formula Weight of Manidipine hydrochloride (89226-75-5): 683.62 g/mol
Synonyms: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride ; 4-(diphenylmethyl)-1-piperazinyl)ethylmethylester,dihydrochloride ; 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride ; Calslot
IUPAC Name: 3-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 5-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
Product Categories: Antihypertensive
Flash Point of Manidipine hydrochloride (89226-75-5): 390.4 °C
Boiling Point of Manidipine hydrochloride (89226-75-5): 722 °C at 760 mmHg
Vapour Pressure of Manidipine hydrochloride (89226-75-5): 1.07E-20 mmHg at 25 °C

Toxicity Data With Reference

1. Mouse LD50 intraperitoneal 62mg/kg (62mg/kg)
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17
2. Mouse LD50 oral 171mg/kg (171mg/kg)
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17
3. Mouse LD50 subcutaneous 340mg/kg (340mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17
4. Rat LD50 intraperitoneal 49mg/kg (49mg/kg)
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17
5. Rat LD50 oral 156mg/kg (156mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17
6. Rat LD50 subcutaneous 199mg/kg (199mg/kg)
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17

Standards and Recommendations

Percent Composition: C 61.49%, H 5.90%, N 8.20%, O 14.04%, Cl 10.37%