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CAS No.: | 9002-01-1 |
---|---|
Name: | STREPTOKINASE |
Molecular Structure: | |
Formula: | Unspecified |
Molecular Weight: | 197.27400 |
Synonyms: | Awelysin;Celiase;Kabikinase;Plasminokinase, streptococcal;Streptase;Streptococcal fibrinolysin;Streptodecase;Streptokinase; |
EINECS: | 232-647-1 |
Density: | 1.113g/cm3 |
Boiling Point: | 343.9oC at 760mmHg |
Flash Point: | 161.8oC |
Hazard Symbols: | B,Xi |
Risk Codes: | 36/37/38 |
Safety: | 22-24/25-36-26 |
PSA: | 49.33000 |
LogP: | 1.95820 |
EINECS: 232-647-1
Storage temp: -20 °C
Sensitive: Hygroscopic
Appearance: White or off-white amorphous powder
Solubility: Soluble in water and saline
Product categories of Streptokinase (CAS NO.9002-01-1): Enzymes;Biochemical products;Therapeutic enzyme
Streptokinase (CAS NO.9002-01-1) has been used as an inexpensive and effective clot-dissolving medication in some cases of myocardial infarction (heart attack) and pulmonary embolism. It may find a use in helping to prevent postoperative adhesions, a common complication of surgery, especially abdominal surgery (appendectomy, gall stones, hysterectomy, etc.)
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
human | TDLo | subcutaneous | 600iu/kg (600iu/kg) | JAMA, Journal of the American Medical Association. Vol. 252, Pg. 1314, 1984. | |
man | TDLo | intravenous | 562500iu/kg (562500iu/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA | JAMA, Journal of the American Medical Association. Vol. 252, Pg. 1314, 1984. |
mouse | LD50 | intraperitoneal | 4200mg/kg (4200mg/kg) | Folia Haematologica Vol. 103, Pg. 445, 1976. | |
mouse | LD50 | intravenous | 3700mg/kg (3700mg/kg) | Farmakologiya i Toksikologiya Vol. 43, Pg. 671, 1980. | |
mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | Folia Haematologica Vol. 103, Pg. 445, 1976. | |
rat | LD50 | intravenous | 2gm/kg (2000mg/kg) | Farmakologiya i Toksikologiya Vol. 43, Pg. 671, 1980. |
Moderately toxic by intravenous route. Human systemic effects by subcutaneous or intravenous routes: effects on the nose, dyspnea and unspecified allergic affects. A thrombolytic agent used to dissolve blood clots in vivo.
Hazard Codes: BXi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Streptokinase ,its cas register number is 9002-01-1. It also can be called SK .It is very unstable in dilute solution and can bind and activate human plasminogen. There are three domains to Streptokinase , denoted β (residues 151–287), α (residues 1–150), and γ (residues 288–414). Each domain binds plasminogen, although none can activate plasminogen independently. One study using animal models (rats) found that when used with a PHBV membrane drug-delivery system, it was 90 percent effective in preventing adhesions. Streptokinase (CAS NO.9002-01-1) is given intravenously as soon as possible after the onset of a heart attack to dissolve clots in the arteries of the heart wall and it is usually given only for a person's first heart attack.