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9002-01-1

Basic Information
CAS No.: 9002-01-1
Name: STREPTOKINASE
Molecular Structure:
Molecular Structure of 9002-01-1 (STREPTOKINASE)
Formula: Unspecified
Molecular Weight: 197.27400
Synonyms: Awelysin;Celiase;Kabikinase;Plasminokinase, streptococcal;Streptase;Streptococcal fibrinolysin;Streptodecase;Streptokinase;
EINECS: 232-647-1
Density: 1.113g/cm3
Boiling Point: 343.9oC at 760mmHg
Flash Point: 161.8oC
Hazard Symbols: B,Xi
Risk Codes: 36/37/38
Safety: 22-24/25-36-26
PSA: 49.33000
LogP: 1.95820
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    streptokinase

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  • Streptokinase

  • Casno:

    9002-01-1

    Streptokinase

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  • Streptokinase manufacturer CAS NO.9002-01-1

  • Casno:

    9002-01-1

    Streptokinase manufacturer CAS NO.9002-01-1

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  • STREPTOKINASE

  • Casno:

    9002-01-1

    STREPTOKINASE

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  • Casno:

    9002-01-1

    STREPTOKINASE

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Chemistry

EINECS: 232-647-1
Storage temp: -20 °C
Sensitive: Hygroscopic
Appearance: White or off-white amorphous powder
Solubility: Soluble in water and saline
Product categories of Streptokinase (CAS NO.9002-01-1): Enzymes;Biochemical products;Therapeutic enzyme

Uses

 Streptokinase (CAS NO.9002-01-1) has been used as an inexpensive and effective clot-dissolving medication in some cases of myocardial infarction (heart attack) and pulmonary embolism. It may find a use in helping to prevent postoperative adhesions, a common complication of surgery, especially abdominal surgery (appendectomy, gall stones, hysterectomy, etc.)

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo subcutaneous 600iu/kg (600iu/kg)   JAMA, Journal of the American Medical Association. Vol. 252, Pg. 1314, 1984.
man TDLo intravenous 562500iu/kg (562500iu/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
JAMA, Journal of the American Medical Association. Vol. 252, Pg. 1314, 1984.
mouse LD50 intraperitoneal 4200mg/kg (4200mg/kg)   Folia Haematologica Vol. 103, Pg. 445, 1976.
mouse LD50 intravenous 3700mg/kg (3700mg/kg)   Farmakologiya i Toksikologiya Vol. 43, Pg. 671, 1980.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Folia Haematologica Vol. 103, Pg. 445, 1976.
rat LD50 intravenous 2gm/kg (2000mg/kg)   Farmakologiya i Toksikologiya Vol. 43, Pg. 671, 1980.
 

Safety Profile

Moderately toxic by intravenous route. Human systemic effects by subcutaneous or intravenous routes: effects on the nose, dyspnea and unspecified allergic affects. A thrombolytic agent used to dissolve blood clots in vivo.
 

Hazard Codes: BiohazardBIrritantXi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36-26
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.

Specification

 Streptokinase ,its cas register number is 9002-01-1. It also can be called SK .It is very unstable in dilute solution and can bind and activate human plasminogen. There are three domains to Streptokinase , denoted β (residues 151–287), α (residues 1–150), and γ (residues 288–414). Each domain binds plasminogen, although none can activate plasminogen independently. One study using animal models (rats) found that when used with a PHBV membrane drug-delivery system, it was 90 percent effective in preventing adhesions. Streptokinase (CAS NO.9002-01-1) is given intravenously as soon as possible after the onset of a heart attack to dissolve clots in the arteries of the heart wall and it is usually given only for a person's first heart attack.