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Basic Information
| CAS No.: | 91-33-8 |
|---|---|
| Name: | BENZTHIAZIDE |
| Molecular Structure: | |
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| Formula: | C15H14 Cl N3 O4 S3 |
| Molecular Weight: | 431.945 |
| Synonyms: | 2H-1,2,4-Benzothiadiazine-7-sulfonamide,3-[(benzylthio)methyl]-6-chloro-, 1,1-dioxide (6CI,8CI);3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine1,1-dioxide; 3-Benzylthiomethyl-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide;3-Benzylthiomethyl-6-chloro-7-sulfamyl-2H-1,2,4-benzothiadiazine 1,1-dioxide;3-[(Benzylthio)methyl]-6-chloro-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; Aquatag; Benzothiazide; Benzthiazide; Dihydrex; Diucen; Diucene;Edemex; ExNa; Exosalt; Fovane; Freeuril; HyDrine; Lemazide; P 1393; Pfizer1393; Proaqua; Regulon; Urese |
| Density: | 1.66g/cm3 |
| Melting Point: | 231-232° (U.S. patent); mp 238-239° (P'an) |
| Boiling Point: | 680.6°C at 760 mmHg |
| Flash Point: | 365.4°C |
| Solubility: | 2.8mg/L(room temperature) |
| Hazard Symbols: |
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| Risk Codes: | 42/43 |
| Safety: | Poison by intravenous route. A diuretic and antihypertensive agent. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−. |
| PSA: | 160.75000 |
| LogP: | 4.86900 |
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BENZTHIAZIDE
Chemistry
Chemical Formula C15H14ClN3O4S3
Uses
Benzothiazide is used to treat hypertension and edema.
Toxicity Data With Reference
| 1. | ivn-rat LD50:422 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 128 (1960),122. | ||
| 2. | ivn-mus LD50:410 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 128 (1960),122. | ||
| 3. | ivn-dog LDLo:200 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 128 (1960),122. |
Safety Profile
Poison by intravenous route. A diuretic and antihypertensive agent. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−.