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Basic Information
CAS No.: 91-75-8
Name: Antazoline
Molecular Structure:
Molecular Structure of 91-75-8 (Antazoline)
Formula: C17H19N3
Molecular Weight: 265.358
Synonyms: 2-Imidazoline,2-[(N-benzylanilino)methyl]- (8CI);2-[(N-Benzylanilino)methyl]-2-imidazoline;Allergan A;Antistine;Phenazoline;
EINECS: 202-094-0
Density: 1.1 g/cm3
Melting Point: 159oC
Boiling Point: 475.5 °C at 760 mmHg
Flash Point: 241.4 °C
Solubility: 663.4mg/L(30 oC)
Appearance: Crystals. Odorless.
PSA: 27.63000
LogP: 2.45930
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Chemistry

Phenazoline is also named as Antazoline;1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-;2-(N-Phenyl-N-benzylaminomethyl)imidazoline;2-[(N-Benzylanilino)methyl]-2-imidazol;2-[(N-Benzylanilino)methyl]-2-imidazoline;2-Imidazoline, 2-[(N-benzylanilino)methyl]-;2-Phenyl-benzyl-amino-methylimidazolin;4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine,and so on.

Molecular Formula: C17H19N3
Molecular Weight: 265.35
EINECS: 202-094-0
Appearance:Crystals. Odorless.
Solubility in water:Insoluble
Melting Point:159 °C
Boiling Point:210 - 220 °C (0.7 torr)
Density:1.188 g/cm3

Uses

Phenazoline is the 1st generation antihistamine used to relieve nasal congestion and in eye drops,and it can be used to relieve the symptoms of allergic.

Toxicity Data With Reference

1.   

eye-rbt 1%

   OPHTAD    Ophtalmologica. 143 (1962),154.
2.   

orl-mus LD50:398 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 7 (1957),237.
3.   

ipr-mus LD50:100 mg/kg

   AEPPAE    Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 237 (1959),171.
4.   

scu-mus LD50:135 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 17 (1967),214.

RTECS:  NJ2000000

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. An eye irritant. When heated to decomposition it emits toxic fumes of NOx.

Hazardous Substances Data: 91-75-8(Hazardous Substances Data)