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| CAS No.: | 92-30-8 |
|---|---|
| Name: | 2-(Trifluoromethyl)phenothiazine |
| Article Data: | 19 |
| Molecular Structure: | |
|
|
|
| Formula: | C13H8F3NS |
| Molecular Weight: | 267.274 |
| Synonyms: | Phenothiazine,2-(trifluoromethyl)- (6CI,7CI,8CI);NSC 50438; |
| EINECS: | 202-145-7 |
| Density: | 1.369 g/cm3 |
| Melting Point: | 188-190 °C(lit.) |
| Boiling Point: | 361.1 °C at 760 mmHg |
| Flash Point: | 172.2 °C |
| Appearance: | yellow to green powder |
| Hazard Symbols: |
 Xn, Xi
|
| Risk Codes: | 20/21/22 |
| Safety: | 36 |
| PSA: | 37.33000 |
| LogP: | 5.05160 |
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Chemistry
IUPAC Name: 2-(trifluoromethyl)-10H-phenothiazine
MF: C13H8F3NS
MW: 267.27
EINECS: 202-145-7
Appearance:Light yellow-green powder
Melting point: 188-190 °C(lit.)
Boiling Point: 361.1 °C at 760 mmHg
Flash Point: 172.2 °C
Density: 1.369 g/cm3
Vapour Pressure: 2.12E-05 mmHg at 25°C
Following is the Molecular Structure of 2-(Trifluoromethyl)phenothiazine (92-30-8):
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Uses
2-(Trifluoromethyl)phenothiazine (92-30-8) can be used as Intermediates of Trifluoperazine hydrochloride .
Production
2-(Trifluoromethyl)phenothiazine (92-30-8) can be produced as following: With 2-carboxy-3-(trifluoromethyl) diphenylamine (synthetic antibacterial agent Montelukast acid) by the high-temperature catalytic decarboxylation (200 ° C, iron powder), generating 3-(Trifluoromethyl) diphenylamine . Then take the 3-(Trifluoromethyl) diphenylamine heating with sulfur with the participation of iodine . After the cyclization,can obtain 2-(Trifluoromethyl)phenothiazine (92-30-8).
Toxicity Data With Reference
| 1. | orl-mus LD50:520 mg/kg | TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Sciences. 12 (1971),110. | ||
| 2. | ivn-mus LD50:32 mg/kg | CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#07426 . |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Poison by intravenous route. Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NOx and F−.
Other safty informations about
Hazard Codes :.gif){kind=small}
Xn(Harmful),.gif){kind=small}
Xi (Irritant)
Risk Statements :20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements :36
S36:Wear suitable protective clothing
WGK Germany :3
RTECS: SP5620000