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93384-43-1

Basic Information
CAS No.: 93384-43-1
Name: Botulin A
Molecular Structure:
Molecular Structure of 93384-43-1 (Botulin A)
Formula: N/A
Molecular Weight: 0
Synonyms: AGN 191622;Allergan (toxin);Botox;Botox Cosmetic;Botulin neurotoxin A;Botulin toxin A;Botulinium toxin type A;Botulinum neurotoxin A;Botulinumtoxin;Botulinum toxin A;Botulinum toxin type A;CBTX-A;Dysport;Linurase;NT201;NT 201 (toxin);Nc 224;Nc 270;Neuronox;Oculinum;OnabotulinumtoxinA;Reloxin;Vistabel;Xeomin;
EINECS: 297-253-4
Density: N/A
Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Solubility: N/A
Appearance: lyophilized powder
Hazard Symbols: VeryT+, ExplosiveB
Risk Codes: 26/27/28-36/38
Safety: 26-28-36/37-45
Transport Information: N/A
PSA: 0.00000
LogP: 0.00000
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    BOTULINUM TOXIN A Basic information Product Name: BOTULINUM TOXIN A Synonyms: botulintoxin;botulinumaneurotoxin;neurotoxin,botulinuma;BT A TOXOID;BOTULINUM TOXIN A;

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    Botulinum toxin Application:Botulinum toxin

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    Botulin AAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

    Welcome to Hangzhou Fandachem Co.,Ltd (www.FandaChem.com) Hangzhou Fandachem Co.,Ltd (Fandachem),an experienced and professional China-based Fine Chemical supplier. We supply the

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    Botulinum toxin

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Specification

With the CAS registry number 93384-43-1, Botulin A is also named as Botulinum Toxin Type A; Onabotulinumtoxina. It is lyophilized powder which is highly toxic and flammable. The product's categories are bacterianeurobiology; cell signaling and neuroscience; pharmacologicals; toxins; toxins and venoms. It will produce spicy smoke when buring. So the storage environment should be ventilate, low-temperature and dry. Keep Botulin A separate from raw materials of food. In addition, it is a protein produced by the bacterium Clostridium botulinum. 

Uses of Botulin A: The Botulin A can be used as an effective and powerful medication. It is mainly used in iatrology and beauty. It is currently used in the treatment of spasms and dystonias, by weakening involved muscles, for the 60-70 day effective period of the drug. This material is also has many other uses, such as treatment of Pediatric incontinence, TMJ pain disorders and Wound healing. But the Botulin A also has many side effects. It can result in inappropriate facial expression such as drooping eyelid, double vision, uneven smile, or loss of the ability to close eyes In cosmetic us. Other adverse events from cosmetic use include headaches, dysphagia, flu-like syndromes, and allergic reactions. 

When you are using this chemical, please be cautious about it as the following:
It is very toxic by inhalation, in contact with skin and if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. After contact with skin, wash immediately with plenty of soap-suds. If you want to contact this product, you must wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD intramuscular > 24units/kg (24units/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: TREMOR

MUSCULOSKELETAL: OTHER CHANGES
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 655, 1997.
mouse LD50 intraperitoneal 160ng/kg (.00016mg/kg)   Toxicology and Applied Pharmacology. Vol. 28, Pg. 227, 1974.
mouse LD50 subcutaneous 4ng/kg (.000004mg/kg)   Toxicon. Vol. 24, Pg. 1065, 1986.
mouse LD50 unreported 30pg/kg (.00000003mg/kg)   Igaku No Ayumi. Progress in Medicine. Vol. 112, Pg. 861, 1980.
rat LD50 intramuscular 96units/kg (96units/kg) MUSCULOSKELETAL: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 655, 1997.
rat LD50 intravenous 50units/kg (50units/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 655, 1997.
rat LDLo subcutaneous 1250mg/kg (1250mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Journal of Physiology. Vol. 260, Pg. 177, 1976.
women TDLo intramuscular 24iu/kg/2W-I (24iu/kg) PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Neurology, Neurosurgery and Psychiatry. Vol. 56, Pg. 220, 1993.