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| CAS No.: | 94-63-3 |
|---|---|
| Name: | PYRIDINE-2-CARBOXALDOXIME METHIODIDE |
| Molecular Structure: | |
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| Formula: | C7H9 N2 O . I |
| Molecular Weight: | 264.066 |
| Synonyms: | 2-Formyl-1-methylpyridiniumiodide oxime (6CI); Pyridinium, 2-[(hydroxyimino)methyl]-1-methyl-, iodide(9CI); Pyridinium, 2-formyl-1-methyl-, iodide, oxime (8CI);1-Methyl-2-aldoximinopyridinium iodide; 1-Methyl-2-hydroxyiminomethylpyridiniumiodide; 2-(Hydroximinomethyl)-1-methylpyridinium iodide;2-Hydroxyiminomethyl-1-methylpyridinium iodide; 2-PAM; 2-PAM iodide;2-Pyridinaldoxime methiodide; 2-Pyridine aldoxime iodomethylate; 2-Pyridinealdoxime methyl iodide; 2-Pyridine aldoxymethiodide; 2-Pyridinealdoximemethiodide; 2-Pyridinecarboxaldehyde aldoxime methiodide; 2-Pyridylaldoximemethiodide; N-Methylpyridine-2-aldoxime iodide; N-Methylpyridinium-2-aldoximeiodide; PAM; PAM (pharmaceutical); Pralidoxime iodide; Pralidoximeiodomethylate; Pralidoxime methiodide; Protopam iodide; Pyridine aldoximemethiodide; Pyridinium-2-aldoxime N-methyliodide |
| EINECS: | 202-349-6 |
| Density: | 1.7439 (estimate) |
| Melting Point: | 220 ºC (dec.) |
| Hazard Symbols: |
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| Risk Codes: | R22 |
| Safety: | Poison by subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Moderately toxic by ingestion. Used as an antidote to the cholinesterase inhibitors of the parathion group. When heated to decomposition it emits highly toxic fumes of NOx and I−. |
| PSA: | 36.47000 |
| LogP: | -2.67680 |
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Chemistry
MF: C7H9IN2O
MW: 264.06
EINECS: 202-349-6
Melting Point: 220 °C (dec.)(lit.)
Appearance of Pyridinium-2-aldoximei-N-methylpyridine (94-63-3): Light yellow needle-like crystalline powder
IUPAC Name: [(E)-(1-methylpyridin-2-ylidene)methyl]-oxoazanium iodide
Synonyms: 1-Methyl-2-aldoximinopyridiniumiodide ; 1-Methyl-2-hydroxyiminomethylpyridiniumiodide ; 2-Formyl-n-methylpyridiniumoximeiodide ; 2-Pamiodide ; 2-Pyridinaldoximmethojodid ; 2-pyridinealdoximeiodomethylate ; N-methylpyridine-2-aldoximeiodide ; N-methylpyridinium-2-aldoximeiodide
Following is the molecular structure of Pyridinium-2-aldoximei-N-methylpyridine (94-63-3):
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Uses
Pyridinium-2-aldoximei-N-methylpyridine (94-63-3)is a family medicine for alkyl phosphate poisoning antidote. The product is a cholinesterase re-activator.
Production
Production methods: Pyridinium-2-aldoximei-N-methylpyridine (94-63-3) is replaced by a pralidoxime chloride. Pralidoxime chloride plus the same amount of water, heating dissolved, stirring dropping potassium iodide saturated solution, precipitation crystallization, filtration, drying. Distilled water then re-crystallization of the activated carbon bleaching was pralidoxime iodide
Toxicity Data With Reference
| 1. | ipr-rat LD50:305 mg/kg | BJPCAL British Journal of Pharmacology and Chemotherapy. 13 (1958),202. | ||
| 2. | ivn-rat LD50:178 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 129 (1960),31. | ||
| 3. | ims-rat LD50:249 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 129 (1960),31. | ||
| 4. | orl-mus LD50:1500 mg/kg | JPMSAE Journal of Pharmaceutical Sciences. 53 (1964),1143. | ||
| 5. | ipr-mus LD50:136 mg/kg | JPMSAE Journal of Pharmaceutical Sciences. 53 (1964),1143. | ||
| 6. | scu-mus LD50:140 mg/kg | AEHLAU Archives of Environmental Health. 5 (1962),21. | ||
| 7. | ivn-mus LD50:134 mg/kg | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,148. | ||
| 8. | ims-mus LD50:240 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 14 (1964),5. |
Safety Profile
Poison by subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Moderately toxic by ingestion. Used as an antidote to the cholinesterase inhibitors of the parathion group. When heated to decomposition it emits highly toxic fumes of NOx and I−.
Safety Information of Pyridinium-2-aldoximei-N-methylpyridine (94-63-3):
Hazard Codes: Xn
Xn: Harmful .gif){kind=small}
Risk Statements: 22
22: Harmful if swallowed
Safety Statements: 36
36: Wear suitable protective clothing
WGK Germany: 3
RTECS: UU4375000