CAS No.98753-19-6,Cefpirome sulfate Suppliers

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Basic Information

Molecular Structure:
CAS No.:	98753-19-6
Name:	Cefpirome sulfate
Article Data:	6

Formula:	C₂₂H₂₂N₆O₅S₂^.H₂SO₄
Molecular Weight:	612.665
Synonyms:	Cefrom;(7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-5-yl)-2-methoxyimino-acetyl]amino]-3-(2-azoniabicyclo[4.3.0]nona-2,4,10-trien-2-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; sulfuric acid;5H-1-Pyrindinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydro-, (6R-(6-alpha,7-beta(Z)))-, sulfate (1:1);5H-1-Pyrindinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydro-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-, sulfate (1:1);CPR;5H-Cyclopenta[b]pyridinium,1-[[7-[[(2-amino- 4-thiazolyl)(methoxyimino)acetyl]amino]-2- carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct- 2-en-3-yl]methyl]-6,7-dihydro-,[6R-[6R,7a- (Z)]]-,sulfate (1:1);1-(((6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydro-5H-1-pyrindinium hydroxide, inner salt, 7(sup 2)-(Z)-(O-methyloxime), sulfate (1:1);HR 810 sulfate;Cefpirome sulfate [USAN:JAN];(6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-(2-azoniabicyclo[4.3.0]nona-2,4,10-trien-2-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; sulfuric acid;Cefrom (TN);Cefpirome sulfate (JP14/USAN);Cefpirome Sulphate (Buffered);Cefpirome Sulphate Sterile;Cefpirome;
EINECS:	685-392-7
Melting Point:	198-202 oC(dec)
Appearance:	white crystalline powder
PSA:	290.44000
LogP:	0.29410

Raw Materials

84957-29-9

104146-10-3

Total:149 Page 1 of 4 1 2 3 4 Next>>

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Chemistry

IUPAC Name: (7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-5-yl)-2-methoxyiminoacetyl]amino]-3-(6,7-dihydro-5H-cyclopenta[b]pyridin-1-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; sulfuric acid
Molecular Formula: C₂₂H₂₂N₆O₅S₂^.H₂SO₄
Molecular Weight: 612.67 g/mol
Canonical SMILES: c1c(sc(n1)N)\C(C(N[C@@H]1C(=O)N2[C@@H]1SCC(C[n+]1c3c(CCC3)ccc1)=C2C(=O)[O-])=O)=N/OC.OS(=O)(=O)O
InChI: InChI=1/C22H22N6O5S2.H2O4S/c1-33-26-15(14-8-24-22(23)35-14)18(29)25-16-19(30)28-17(21(31)32)12(10-34-20(16)28)9-27-7-3-5-11-4-2-6-13(11)27;1-5(2,3)4/h3,5,7-8,16,20H,2,4,6,9-10H2,1H3,(H3-,23,24,25,26,29,31,32);(H2,1,2,3,4)/t16-,20?;/m1./s1
Classification Code: Antibacterial; Drug / Therapeutic Agent; Reproductive Effect
Product Categories: Antibacterial; Miscellaneous; cephalosporins antibiotics; Intermediates & Fine Chemicals; Pharmaceuticals
H-Bond Donor: 4
H-Bond Acceptor: 12
Melting Point: 198-202 °C
Storage temperature of Cefpirome sulfate (CAS NO.98753-19-6): Store at 0-5 °C

Uses

Cefpirome sulfate (CAS NO.98753-19-6) is used as fourth generation cephalosporin antibiotic.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
monkey	LD50	intravenous	1414mg/kg (1414mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 2178, 1993.
mouse	LD50	intraperitoneal	3850mg/kg (3850mg/kg)		Journal of Toxicological Sciences. Vol. 15(Suppl,
mouse	LD50	intravenous	2400mg/kg (2400mg/kg)		Journal of Toxicological Sciences. Vol. 15(Suppl,
mouse	LD50	oral	16200mg/kg (16200mg/kg)		Journal of Toxicological Sciences. Vol. 15(Suppl,
rabbit	LDLo	intravenous	2gm/kg (2000mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION KIDNEY, URETER, AND BLADDER: CHANGES IN BLADDER WEIGHT	Journal of Toxicological Sciences. Vol. 15(Suppl,
rat	LD50	intraperitoneal	5800mg/kg (5800mg/kg)		Journal of Toxicological Sciences. Vol. 15(Suppl,
rat	LD50	intravenous	1900mg/kg (1900mg/kg)		Journal of Toxicological Sciences. Vol. 15(Suppl,
rat	LD50	oral	> 8gm/kg (8000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Toxicological Sciences. Vol. 15(Suppl,
rat	LD50	subcutaneous	> 10gm/kg (10000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Toxicological Sciences. Vol. 15(Suppl,

Specification

Cefpirome sulfate (CAS NO.98753-19-6), its Synonyms are 1-(((6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydro-5H-1-pyrindinium hydroxide, inner salt, 7(sup 2)-(Z)-(O-methyloxime), sulfate (1:1) ; 5H-1-Pyrindinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydro-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-, sulfate (1:1) ; Cefrom ; HR 810 sulfate . It is white crystalline powder.