1005-06-7Relevant articles and documents
Dihydroxy pyrimidine compound and use thereof
-
, (2019/07/04)
The invention provides a dihydroxy pyrimidine compound, its structural general formula is: Wherein R1 In order to contain the substituent of the aryl, heterocyclic or containing substituent is C1 - C6 alkyl; R2 Is C1 - C6 alkyl, C1 - C6 alkyl aryl, C1 - C6 alkyl heterocyclic group or a hydrogen atom; x, y each is between 0 - 6 is any natural number. The invention also provides a two-hydroxy pyrimidine compounds in the preparation of anti-influenza virus in the application. The present invention provides a dihydroxy pyrimidine compounds to the influenza virus activity has better inhibition, can remarkably reduce the toxicity of the influenza virus, and cytotoxicity is relatively low, thus can such compounds for the preparation of anti-influenza virus drugs.
Pyrrolo[2,3-d] pyrimidines as antiviral agents
-
Scheme 2, (2010/11/29)
This invention relates to a novel class of 4,5,6,7-substituted non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidines which exhibit both significantly lower levels of cytotoxicity and superior antiviral activity than known nucleoside, non-nucleoside, and non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidine derivatives, particularly against human DNA viruses such as cytomegalovirus (HCMV) and herpes simplex virus type 1 (HSV-1). These compounds are represented by the following formula: wherein: R4is —NR1R2or oxo; R5is —CN, or —CSNR1R2, or —CONR1R2; R6is —H, or halo, or —NR1R2; wherein R1and R2are independently —H or an aliphatic group; and R7is of the formula R3—Ar, wherein R3is an aliphatic group and Ar is an unsubstituted aryl or an aryl independently substituted with halo, nitro, amino, or aliphatic groups; provided that when R5is a —CN or —CSNH2, and R6is a —H or —NH2, and Ar is a —C6H5or a phenyl substituted with only one aliphatic group, R3is an aliphatic group other than methyl such that —R3— is not a —CH2—; and pharmaceutically acceptable salts, prodrugs and derivatives thereof.
A new synthesis of 3-substituted-1H-indenes through reaction of o-(β-magnesioalkyl)phenylmagnesium dihalides with carboxylate esters
Baker, Robert W.,Foulkes, Michael A.,Griggs, Michael,Nguyen, Bao N.
, p. 9319 - 9322 (2007/10/03)
A new synthesis of 3-substituted-1H-indenes has been developed through the reaction of o-(β-magnesioalkyl)phenylmagnesium dihalides with carboxylate esters, followed by dehydration of the intermediate 1-substituted-1-indanols. Di-Grignard reagents allowing the synthesis of 3-substituted-, 2-methyl-3-substituted-, and 4-methyl-3-substituted-1H-indenes have been prepared, with overall yields for the two-step sequence ranging from 45 to 95%.
