105310-09-6

• 

• Basic information

  1. Product Name: Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, cis-
  2. Synonyms:
  3. CAS NO:105310-09-6
  4. Molecular Formula: C15H22N2O
  5. Molecular Weight: 246.352
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 105310-09-6.mol
  9. Article Data: 8

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: N/A
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, cis-(CAS DataBase Reference)
  10. NIST Chemistry Reference: Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, cis-(105310-09-6)
  11. EPA Substance Registry System: Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, cis-(105310-09-6)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 105310-09-6(Hazardous Substances Data)

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• Downstream Products
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105310-09-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 105310-09-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,3,1 and 0 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 105310-09:
(8*1)+(7*0)+(6*5)+(5*3)+(4*1)+(3*0)+(2*0)+(1*9)=66
66 % 10 = 6
So 105310-09-6 is a valid CAS Registry Number.

105310-09-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name	milnacipran

1.2 Other means of identification

Product number	-
Other names	cis-milnacipran

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105310-09-6 SDS

105310-09-6Upstream product

• 1353644-50-4 (1SR,2RS)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropane carboxamide 
• 140-29-4 phenylacetonitrile 
• 86181-08-0 cis-(±)-1-phenyl-2-(aminomethyl)-N,N-diethylcyclopropanecarboxamide hydrochloride 
• 105310-90-5 (Z)-1-phenyl-2-(bromomethyl)-N,N-diethylcyclopropanecarboxamide 
• 105310-66-5 (1S,2R)/(1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid chloride 
• 69160-63-0 (1S,2R)/(1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid 
• 105310-75-6 (1SR,2RS)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropane carboxamide 

105310-09-6Downstream Products

• 1031898-60-8 (-)-(1R,2S)-1-phenyl-2-(aminomethyl)cyclopropane-N,N-diethyl-carboxamide L-di-p-toluoyl-tartrate 
• 96847-54-0 (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide 
• 1031898-58-4 (+)-(1S,2R)-1-phenyl-2-(aminomethyl)cyclopropane-N,N-diethyl-carboxamide D-di-p-methoxybenzoyl-tartrate 
• 96847-54-0 (1R,2S)-milnacipran 
• 86181-08-0 cis-(±)-1-phenyl-2-(aminomethyl)-N,N-diethylcyclopropanecarboxamide hydrochloride 

105310-09-6Relevant articles and documents

Synthesis and characterization of process related impurities of (±)-Milnacipran

Raja Gopal,Christy Prabakar,Chandrashekar,Vijaya Bhaskard,Veera Somaiah

, p. 639 - 644 (2013)

Milnacipran is a cyclopropane derivative, used as an anti depressant drug. During the process development of milnacipran, four process related potential impurities were detected in high performance liquid chromatography. All these impurities were identified, synthesized and subsequently characterized by their respective spectral data (IR, LC-MS, 1HNMR, and 13C NMR) as described in this article.

PROCESS FOR THE PREPARATION OF (±M1R(S), 2SRR)L-2-(AMINOMETHYL)-N,N-DIETHYL-L-PHENYLCYCLOPROPANE CARBOXAMIDE HYDROCHLORIDE

-

, (2012/04/23)

The present invention relates to an improved process for the preparation of (±)-[1R(S),2S(R)]-2-(aminomethyl)-N,N-diethyl-l-phenylcyclopropane carboxamide hydrochloride compound of formula- la.

PROCESS FOR PREPARING OPTICALLY PURE MILNACIPRAN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

-

Page/Page column 12, (2012/12/13)

The present invention relates to an improved and commercially, viable process for the resolution of racemic cis milnacipran of formula I and its pharmaceutically acceptable salts of formula II. The present invention comprises using racemic cis milnacipran or its pharmaceutically acceptable salts as starting material, a low cost and commercially available resolving agent of formula III and industrially safe and economically low cost material such as water as a solvent. The said process results into optical isomers of racemic cis milnacipran having excellent optical purity without involving multiple crystallization steps. The present invention also comprises the concept of green chemistry as the invention works well with water as a solvent thereby minimizing the use of any other solvent. (Formular I and II should be inserted here) Wherein X is anion selected from Cl, Br, I, HSO4, Phosphate or organic acid (Formular III should be inserted here) *represent asymmetric centre Compound of formula III represent mandelic acid and its derivatives.

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