86181-08-0

Upstream product

• 63106-93-4 1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one 
• 105310-09-6 milnacipran 
• 105310-75-6 (1SR,2RS)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropane carboxamide 
• 1353644-50-4 (1SR,2RS)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropane carboxamide 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 105310-09-6 milnacipran 
• 105310-28-9 (+/-)-(Z)-1-phenyl-2-(aminomethyl)cyclopropanecarboxylic acid hydrochloride 
• 1374648-80-2 (1S,2R)-cis-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide (D)-(-)-mandelate 
• 1374648-84-6 (1R,2S)-cis-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide (L)-(+)-mandelate 
• 101152-94-7 (1S,2R)-milnacipran hydrochloride 
• 96847-54-0 (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide 
• 96847-54-0 (1R,2S)-milnacipran 
• 101152-94-7 (1R,2S)-cis-milnacipran hydrochloride 

Relevant academic research and scientific papers

Drug intermediate as well as preparation and application thereof

The invention designs a drug intermediate III, and the structural formula of the drug intermediate III is shown in the specification.

IMPROVED PROCESS FOR THE PREPARATION OF LEVOMILNACIPRAN

The present invention discloses cost-effective, industrially efficient and safe process synthesis of levomilnacipran that is devoid of 1-phenyl-1- diethylaminocarbonyl-2- chloromethylcyclopropane.

An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde

An efficient synthesis of milnacipran hydrochloride has been accomplished. The important application of this paper is the reductive amination of aldehyde to primary amine with water soluble reagents. This method provides a high yield of primary amine as t

Intermediate milnacipran hydrochloride and its preparation method and application

The invention relates to the technical field of synthetic methods of milnacipran hydrochloride. The preparation method provided by the invention comprises the following steps: carrying out reactions in five steps on an existing compound to generate a nove

PROCESS FOR THE PREPARATION OF (±M1R(S), 2SRR)L-2-(AMINOMETHYL)-N,N-DIETHYL-L-PHENYLCYCLOPROPANE CARBOXAMIDE HYDROCHLORIDE

The present invention relates to an improved process for the preparation of (±)-[1R(S),2S(R)]-2-(aminomethyl)-N,N-diethyl-l-phenylcyclopropane carboxamide hydrochloride compound of formula- la.

PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACCEPTABLE SALTS OF RACEMIC MILNACIPRAN AND ITS OPTICAL ENANTIOMERS THEREOF

The present invention relates to an improved process for the preparation of pharmaceutically acceptable salts of milnacipran by mutual acid radical exchange.

PROCESS FOR PREPARATION OF MILNACIPRAN INTERMEDIATE AND ITS USE IN PREPARATION OF PURE MILNACIPRAN

Disclosed is a process for the preparation of milnacipran intermediate, a compound of formula ΙII, and its use in the preparation of pure milnacipran.