96847-54-0

Basic information

• Product Name: L-Milnacipran Hydrochloride
• Synonyms: (1S,2R)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide
• CAS NO: 96847-54-0
• Molecular Formula: C15H22N2O
• Molecular Weight: 246.34798
• Mol File: 96847-54-0.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 393.0±21.0 °C(Predicted)
• Appearance: /
• Density: 1.077±0.06 g/cm3(Predicted)
• PKA: 10.36±0.29(Predicted)
• CAS DataBase Reference: L-Milnacipran Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Milnacipran Hydrochloride(96847-54-0)
• EPA Substance Registry System: L-Milnacipran Hydrochloride(96847-54-0)

Safety Data

• Hazardous Substances Data: 96847-54-0(Hazardous Substances Data)

Upstream product

• 105310-75-6 (1R,2R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide 
• 105310-75-6 (1SR,2RS)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropane carboxamide 
• 32634-66-5 Di-p-toluoyl-L-tartaric acid 
• 105310-09-6 milnacipran 
• 140-29-4 phenylacetonitrile 
• 172015-99-5 (1 S,2 R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropane-carboxamide 
• 1001017-62-4 (1S,2R)-2-(bromomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide 
• 174848-98-7 (1S,2R)-2-(azidomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide 
• 50583-51-2 O,O′-di-p-anisoyl-D-tartaric acid 
• 172016-06-7 (1R,2S)-1-phenyl-2-(hydroxymethyl)-N,N-diethylcyclopropanecarboxamide 
• 96847-52-8 (1R,2S)-2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane 
• 345349-97-5 (1R,2S)-1-phenyl-2-(azidomethyl)-N,N-diethylcyclopropanecarboxamide 
• 1353644-50-4 (1SR,2RS)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropane carboxamide 
• 86181-08-0 cis-(±)-1-phenyl-2-(aminomethyl)-N,N-diethylcyclopropanecarboxamide hydrochloride 

Downstream Products

• 96847-54-0 (1R,2S)-milnacipran 
• 96847-54-0 (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide 
• 1418000-39-1 N,N-diethyl-2-methyl-1-phenylcycloprop-2-enecarboxamide 
• 105310-06-3 2-(aminomethyl)-1-phenylcyclopropanecarboxamide 

Relevant articles and documents

Preparation method of milnacipra hydrochloride intermediate

The invention provides a preparation method of an intermediate hydrochloride intermediate. Belong to chemical medicine preparation technical field. To the preparation method, the compound having the structure of the formula (II) is added into the methanol

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

PROCESS FOR PREPARING LEVOMILNACIPRAN

The present invention refers to a new process for preparing levomilnacipran, in particular to a process for the resolution of racemic tw-milnacipran with a derivative of optically active phenylglycine.