107905-52-2 Usage
Chemical Properties
Colourless Liquid
Synthesis
KHMDS (7.50 mL, 3.75 mmol, 0.5 M in toluene) was added to a solution of 18-
crown-6 (4.10 g, 15.51 mmol), THF (20 mL), and bis (2,2,2-trifluoroethyl) phosphite (1)
(0.50 mL, 3.41 mmol) by syringe in a dropwise manner at -78 ℃. Following 15 min,
ethyl 2-bromopropionate (0.40 mL, 3.08 mmol) was added to the round bottom flask and
the reaction mixture was allowed to stir for 4 hr at room temperature. Following the
standard workup procedure, the crude product was then purified by flash column
chromatography (3:1 to 2:1 hexanes:EtOAc, Rf
= 0.33 in 1:1 hexanes:EtOAc) yielding
Ethyl 2-[Bis(2,2,2-trifluoroethyl)phosphono] Propionate (112 mg, 0.33 mmol, 10.5%) as a yellow syrup.
Check Digit Verification of cas no
The CAS Registry Mumber 107905-52-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,9,0 and 5 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 107905-52:
(8*1)+(7*0)+(6*7)+(5*9)+(4*0)+(3*5)+(2*5)+(1*2)=122
122 % 10 = 2
So 107905-52-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H13F6O5P/c1-3-18-7(16)6(2)21(17,19-4-8(10,11)12)20-5-9(13,14)15/h6H,3-5H2,1-2H3
107905-52-2Relevant articles and documents
A new bis(2,2,2-trifluoroethyl)phosphonate for the synthesis of Z-unsaturated N-methoxy-N-methylamides
Fortin, Samuel,Dupont, Felix,Deslongchamps, Pierre
, p. 5437 - 5439 (2002)
The N-methoxy-N-methyl bis(2,2,2-trifluoroethyl)phosphonamide was easily obtained via the Arbuzov reaction with use of commercially available tris(2,2,2-trifluoroethyl)phosphite, 2-bromo-N-methoxy-N-methylacetamide, and KF/alumina. The reaction of bis(2,2,2-trifluoroethyl)phosphonate with several aldehydes demonstrates the versatility of the method, which gives Z-unsaturated amides in good yields.
Michaelis-Becker synthesis of bis(2,2,2-trifluoroethyl)phosphono esters
Ciszewski, Gregory M.,Jackson, John A.
, p. 240 - 243 (2007/10/03)
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