1091627-77-8 Usage
Description
22-Amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 1,1-dimethylethyl ester, also known as Boc-N-amido-PEG6-Amine, is a heterobifunctional polyethylene glycol (PEG) derivative. It is a monodisperse PEG reagent with a hydrophilic PEG spacer that increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, and other functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses
Used in Intramolecular Linking Agents:
22-Amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 1,1-dimethylethyl ester is used as an intramolecular linking agent for the preparation of various bioconjugates and macromolecular structures. The hydrophilic PEG spacer allows for increased solubility and stability in aqueous environments, while the reactive amino group enables the formation of stable amide bonds with carboxylic acids and other functional groups.
Used in Pharmaceutical and Biomedical Applications:
In the pharmaceutical and biomedical industries, 22-Amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 1,1-dimethylethyl ester is used as a building block for the synthesis of drug delivery systems, diagnostic agents, and therapeutic agents. The PEGylation of these agents can improve their solubility, stability, and bioavailability, as well as reduce their immunogenicity and non-specific interactions with biological systems.
Used in Chemical Synthesis:
22-Amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 1,1-dimethylethyl ester is also used in chemical synthesis as a versatile reagent for the preparation of various PEGylated compounds. The Boc-protected amino group allows for selective deprotection and subsequent coupling reactions, enabling the synthesis of complex PEG-based structures with precise control over molecular architecture and functionality.
Check Digit Verification of cas no
The CAS Registry Mumber 1091627-77-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,1,6,2 and 7 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1091627-77:
(9*1)+(8*0)+(7*9)+(6*1)+(5*6)+(4*2)+(3*7)+(2*7)+(1*7)=158
158 % 10 = 8
So 1091627-77-8 is a valid CAS Registry Number.
1091627-77-8Relevant articles and documents
Modular synthesis of bifunctional linkers for materials science
Moreau, Julie,Marchand-Brynaert, Jacqueline
, p. 1641 - 1644 (2011/05/03)
A practical synthesis of α,ω-bifunctional linkers is described that is based on three building blocks, namely, thioctic acid, a spacer-arm of seven ethylene glycol units, and a functional motif dedicated to the selective immobilization of purposely tagged proteins. Such representative motifs are biotin, haloacetamide, maleimide, and nitrilotriacetic acid derivatives. The building blocks are connected through alkyl, amide, and/or carbamate linkages. Copyright
