1292268-15-5

Basic information

• Product Name: t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate
• Synonyms: t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate
• CAS NO: 1292268-15-5
• Molecular Weight: 450.533
• Mol File: 1292268-15-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate(1292268-15-5)
• EPA Substance Registry System: t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate(1292268-15-5)

Safety Data

• Hazardous Substances Data: 1292268-15-5(Hazardous Substances Data)

Usage

Description

t-boc-N-amido-PEG6-azide is a azide containing crosslinking reagent with a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The reagent can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Upstream product

• 1091627-77-8 tert-butyl (20-amino-3,6,9,12,15,18-hexaoxaicosyl)carbamate 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 139115-92-7 tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamate 
• 77544-68-4 8-tosyloxy-3,6-dioxaoctanol 
• 86520-52-7 2-[2-(2-azidoethoxy)ethoxy]ethanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 6338-55-2 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol 
• 1292268-14-4 2,2-dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-yl 4-methylbenzenesulfonate 
• 1292268-13-3 t-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosylcarbamate 
• 430430-57-2 2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecane-13-yl methanesulfonate 

Relevant articles and documents

Oligo(ethylene glycol)-based thermosensitive dendrimers and their tumor accumulation and penetration

Dendrimers have several featured advantages over other nanomaterials as drug carriers, such as well-defined structure, specific low-nanometer size, and abundant peripheral derivable groups, etc. However, these advantages have not been fully exploited yet to optimize their biological performance, especially tumor penetration, which is a shortcoming of current nanomaterials. Here we show the syntheses of a new class of oligo(ethylene glycol) (OEG)-based thermosensitive dendrimers up to the fourth generation. Each dendrimer shows monodisperse structure. OEG/poly(ethylene glycol) (PEG) moieties with different precise lengths were introduced to the periphery of the fourth-generation dendrimer followed by an antitumor agent, gemcitabine (GEM). The biodistributions of the GEM-conjugated dendrimers were investigated by micro positron emission tomography and multispectral optoacoustic tomography imaging techniques and compared with that of GEM-conjugated poly(amidoamine) (PAMAM). The GEM-conjugated dendrimer with the longest peripheral PEG segments exhibited the most desirable tumor accumulation and penetration and thus had significantly higher antitumor activity than the GEM-conjugated PAMAM.