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t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate is an azide-containing crosslinking reagent with a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The reagent can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Used in Chemical Synthesis:
t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate is used as a crosslinking reagent for the formation of stable triazole linkages through Click Chemistry with alkyne, BCN, and DBCO. The Boc-protected amino group allows for mild acidic deprotection to form the free amine, enhancing the reactivity and versatility of the compound in various chemical synthesis applications.
Used in Drug Delivery Systems:
t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate is used as a component in the development of drug delivery systems, where its crosslinking properties and Boc-protected amino group can be utilized to improve the stability, solubility, and targeting of therapeutic agents.
Used in Bioconjugation:
t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate is used as a bioconjugation agent to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to various surfaces or other biomolecules. The hydrophilic PEG spacer and stable triazole linkages provide enhanced stability and reduced immunogenicity in biological systems.
Used in Materials Science:
t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate is used in the development of functional materials, such as hydrogels, nanoparticles, or self-assembled structures, where its crosslinking properties and Boc-protected amino group can be employed to create materials with tailored properties and functions.

1292268-15-5

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1292268-15-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1292268-15-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,9,2,2,6 and 8 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1292268-15:
(9*1)+(8*2)+(7*9)+(6*2)+(5*2)+(4*6)+(3*8)+(2*1)+(1*5)=165
165 % 10 = 5
So 1292268-15-5 is a valid CAS Registry Number.

1292268-15-5Downstream Products

1292268-15-5Relevant academic research and scientific papers

Oligo(ethylene glycol)-based thermosensitive dendrimers and their tumor accumulation and penetration

Wu, Wei,Driessen, Wouter,Jiang, Xiqun

supporting information, p. 3145 - 3155 (2014/03/21)

Dendrimers have several featured advantages over other nanomaterials as drug carriers, such as well-defined structure, specific low-nanometer size, and abundant peripheral derivable groups, etc. However, these advantages have not been fully exploited yet to optimize their biological performance, especially tumor penetration, which is a shortcoming of current nanomaterials. Here we show the syntheses of a new class of oligo(ethylene glycol) (OEG)-based thermosensitive dendrimers up to the fourth generation. Each dendrimer shows monodisperse structure. OEG/poly(ethylene glycol) (PEG) moieties with different precise lengths were introduced to the periphery of the fourth-generation dendrimer followed by an antitumor agent, gemcitabine (GEM). The biodistributions of the GEM-conjugated dendrimers were investigated by micro positron emission tomography and multispectral optoacoustic tomography imaging techniques and compared with that of GEM-conjugated poly(amidoamine) (PAMAM). The GEM-conjugated dendrimer with the longest peripheral PEG segments exhibited the most desirable tumor accumulation and penetration and thus had significantly higher antitumor activity than the GEM-conjugated PAMAM.

Modular synthesis of bifunctional linkers for materials science

Moreau, Julie,Marchand-Brynaert, Jacqueline

, p. 1641 - 1644 (2011/05/03)

A practical synthesis of α,ω-bifunctional linkers is described that is based on three building blocks, namely, thioctic acid, a spacer-arm of seven ethylene glycol units, and a functional motif dedicated to the selective immobilization of purposely tagged proteins. Such representative motifs are biotin, haloacetamide, maleimide, and nitrilotriacetic acid derivatives. The building blocks are connected through alkyl, amide, and/or carbamate linkages. Copyright

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