112298-41-6Relevant articles and documents
Palladium-catalyzed cross-coupling of unactivated alkylzinc reagents with 2-bromo-3,3,3-trifluoropropene and its application in the synthesis of fluorinated amino acids
Lou, Yue-Guang,Wang, An-Jun,Zhao, Liang,He, Lin-Feng,Li, Xiao-Fei,He, Chun-Yang,Zhang, Xingang
supporting information, p. 3705 - 3708 (2019/04/01)
A palladium-catalyzed cross-coupling of unactivated alkylzinc reagents with 2-bromo-3,3,3-trifluoropropene (BTP) has been developed, which was used as a key step to prepare a series of trifluoromethylated and difluoromethylated amino acids that are of great interest in peptide/protein based chemical biology. The advantages of the synthesis of these fluorinated amino acids are synthetic simplicity and diversity from a simple and readily available key intermediate α-trifluoromethylalkene-containing amino acid, providing a facile route for applications in medicinal chemistry and life science.
Trifluoromethylated allylic anion and radical; generation by the electronic inversion of π-allylic palladium complex by samarium diiodide
Hanzawa,Ishizawa,Kobayashi,Taguchi
, p. 1104 - 1106 (2007/10/02)
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