113085-06-6Relevant articles and documents
Process of separating chiral isomers of chroman compounds and their derivatives and precursors
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Page/Page column 14, (2012/12/13)
The present invention relates to a process of separating chiral isomers of chroman compounds, particularly tocopherols and tocotrienols as well as the esters and intermediates thereof. It has been found that this process allows a separation of the desired isomer with a higher yield and enables the use of the non-desired isomers in a very efficient way. Said process is particularly useful when implemented in an industrial process. Furthermore, it has been found that this process allows using isomer mixtures as they result from traditional industrial synthesis.
Electron Transfer Reactions of Halothane-derived Peroxyl Free Radicals, CF3CHClO2.: Measurement of Absolute Rate Constants by Pulse Radiolysis
Moenig, Joerg,Asmus, Klaus-Dieter,Schaeffer, Michel,Slater, Trevor F.,Willson, Robin L.
, p. 1133 - 1138 (2007/10/02)
The halothane-derived peroxyl radical CF3CHClO2. has been generated in aqueous solutions by pulse radiolysis.Absolute rate constants for the reduction of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) by hydrated electrons, hydrogen atoms, and propan-2-ol free radicals have been determined to be k 1.4E10, 3.8E8, and 7.6E7 l mol-1 s-1, respectively.The predominant product radical CF3CHCl rapidly adds O2, and an estimate of k 1.3E9 l mol-1 s-1, has been obtained for the absolute rate constant of this reaction.The resulting peroxyl radical CF3CHClO2. has been found to react rapidly with a variety of nucleophilic compounds such as 2,2'-azinobis(3-ethylbenzthiazoline-6-sulphonate), the phenothiazines promethazine, chlorpromazine, and metiazinic acid, the vitamins C and E, and propyl gallate.The absolute rate constants for these reactions are found to be generally lower than for corresponding reactions of the carbon tetrachloride-derived radical, CCl3O2..
