113100-61-1Relevant articles and documents
SPIRO-SULFONIMIDAMIDE DERIVATIVES AS INHIBITORS OF MYELOID CELL LEUKEMIA-1 (MCL-1) PROTEIN
-
Paragraph 00377, (2021/10/22)
The disclosure is directed to compounds of Formula (I). Pharmaceutical compositions comprising compounds of Formula (I) as well as methods of their use and preparation, are also described.
(1H-pyrazole-4-carboxamido) ethyl benzoate compound as well as preparation method and application thereof
-
Paragraph 0140; 0147, (2020/01/08)
The invention discloses an ethyl (1H-pyrazole-4-carboxamido) benzoate compound as well as a preparation method and application thereof. The structural formula of the (1H-pyrazole-4-carboxamido) ethylbenzoate compound is as shown in the formula (I), wherein the substituent groups R1 are phenyl or substituted phenyl, the number of substituent groups on a benzene ring of the substituted phenyl is one or more, and each substituent group is independently selected from H, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C3 halogenated alkyl or nitro; and the substituent R2 is methyl, monofluoromethyl, difluoromethyl or trifluoromethyl. The invention discloses a novel compound with bactericidal activity, which is simple in preparation method and convenient to operate, and the obtained compound has betterinhibitory activity on pathogenic bacteria such as cucumber botrytis cinerea, fusarium oxysporum, cucumber corynespora leaf spot and the like under the concentration of 50 mg/mL.
1,3-dimethyl-1H-pyrazole-4-amide derivative as well as preparation method and application thereof
-
Paragraph 0030; 0035; 0036, (2018/06/16)
The invention relates to a 1,3-dimethyl-1H-pyrazole-4-amide derivative as well as a preparation method and application thereof. The derivative is prepared by the steps of carrying out reflux on ethylacetoacetate and triethyl orthoformate in acetic anhydride, adding into methylhydrazine so as to prepare 1,3-dimethyl-1H-pyrazole-4-ethyl formate, carrying out hydrolysis, adding hydrochloric acid soas to prepare 1,3-dimethyl-1H-pyrazole-4-carboxylic acid, reacting by virtue of 1,3-dimethyl-1H-pyrazole-4-carboxylic acid and sulfoxide chloride, adding dichloromethane for dilution, and adding arylalkylamine and triethylamine, so as to prepare the 1,3-dimethyl-1H-pyrazole-4-amide derivative. The preparation method is simple and convenient in operation; the obtained compound has optimal inhibitory activity to sclerotinia sclerotiorum at 50ppm, and the inhibition ratio reaches 87.5%; the obtained compound has relatively good inhibitory activity to macrophoma kawatsukai, and the inhibition ratio is equal to that of a contrast medicament; and the compound is a novel compound with bactericidal activity, and the foundation is provided for the research and development of novel pesticides.
