1205-62-5Relevant articles and documents
Erratum: Serendipitous assemblies of two large phosphonate cages: A Co 15 distorted molecular cube and a Co12 butterfly type core structure (Inorganic Chemistry (2013) 52:8 (4127-4129) DOI: 10.1021/ic3025183)
Sheikh, Javeed Ahmad,Goswami, Soumyabrata,Adhikary, Amit,Konar, Sanjit
, p. 6765 - 6765 (2013)
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Synthesis, crystal structure and computational studies of 4-nitrobenzylphosphonic acid
Wilk, Magdalena,Jarzembska, Katarzyna N.,Janczak, Jan,Hoffmann, Józef,Videnova-Adrabinska, Veneta
, p. 240 - 249 (2014)
4-Nitrobenzylphosphonic acid (1a) has been synthesized and structurally characterized by vibrational spectroscopy (IR and Raman) and single-crystal X-ray diffraction. Additionally, Hirshfeld surface analysis and computational methods have been used to com
Designing anti-inflammatory drugs from parasitic worms: A synthetic small molecule analogue of the acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis
Al-Riyami, Lamyaa,Pineda, Miguel A.,Rzepecka, Justyna,Huggan, Judith K.,Khalaf, Abedawn I.,Suckling, Colin J.,Scott, Fraser J.,Rodgers, David T.,Harnett, Margaret M.,Harnett, William
, p. 9982 - 10002 (2014/01/17)
In spite of increasing evidence that parasitic worms may protect humans from developing allergic and autoimmune diseases and the continuing identification of defined helminth-derived immunomodulatory molecules, to date no new anti-inflammatory drugs have been developed from these organisms. We have approached this matter in a novel manner by synthesizing a library of drug-like small molecules based upon phosphorylcholine, the active moiety of the anti-inflammatory Acanthocheilonema viteae product, ES-62, which as an immunogenic protein is unsuitable for use as a drug. Following preliminary in vitro screening for inhibitory effects on relevant macrophage cytokine responses, a sulfone-containing phosphorylcholine analogue (11a) was selected for testing in an in vivo model of inflammation, collagen-induced arthritis (CIA). Testing revealed that 11a was as effective as ES-62 in protecting DBA/1 mice from developing CIA and mirrored its mechanism of action in downregulating the TLR/IL-1R transducer, MyD88. 11a is thus a novel prototype for anti-inflammatory drug development.