126145-23-1Relevant articles and documents
New process for the synthesis of moguisteine
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Page/Page column 14-15; 20, (2009/07/10)
The invention relates to a process for the synthesis of moguisteine that is ethyl ester of (R,S)-3-[2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl]-3-oxypropanoic acid which comprises the steps of forming a new cyclic intermediate of formula 2-[(2-methoxyphenoxy)methyl]-1,3-dioxolane (4), forming (R,S)-2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidine (6) and reacting this latter with monoethylmalonic acid (7) or a salt thereof. The moguisteine of the invention is obtained in high yield and purity.
β-carbonyl-carboxyamides of 1,3-thiazolidines
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, (2008/06/13)
This application relates to compounds of formula I; STR1 wherein R is hydrogen, a linear or branched C1 -C4 -alkyl, allyl or propargyl; X is O, CH2 or S; R1 is --(CH2)n Ra, hydroxy, --O--(CH2)n Ra, --NRbRc or --NH c(CH2)m --NRbRc; Ra is hydrogen, a linear or branched C1 -CH4 -alkyl, phenyl, p-methoxy-phenyl, 3,4,5-trimethoxyphenyl, B-pyryidyl, cyclopentyl or cyclohexyl; Rb and Rc, can be the same or different and are selected independently in the group of hydrogen, linear or branched C1 -C4 -alkyl, cyclohexyl, cyclopentyl, benzyl, hexahydrobenzyl, α,β or γ-pyridylmethyl; or Rb and Rc taken together with the N atom to which they are bound can form a morpholino, piperidino or piperazino residue of formula Rd--N(CH2 --CH2)2 --N-- wherein Rd is hydrogen, linear or branched C1 -C4 -alkyl, benzyl, hexahydrobenzyl, (C6 H5)2 CH--, (p--F--C6 H4)2 CH or B-pyridylmethyl; n is zero or an integer from 1 to 3 and m is 2 or 3; and a process for the preparation thereof.
