103181-68-6Relevant articles and documents
New process for the synthesis of moguisteine
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Page/Page column 12; 13; 20, (2009/07/10)
The invention relates to a process for the synthesis of moguisteine that is ethyl ester of (R,S)-3-[2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl]-3-oxypropanoic acid which comprises the steps of forming a new cyclic intermediate of formula 2-[(2-methoxyphenoxy)methyl]-1,3-dioxolane (4), forming (R,S)-2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidine (6) and reacting this latter with monoethylmalonic acid (7) or a salt thereof. The moguisteine of the invention is obtained in high yield and purity.
Antitussive and mucus regulating 2-substituted thiazolidines
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, (2008/06/13)
2-Substituted thiazolidines compounds having formula I STR1 wherein X is a CH2, O or S, R is hydroxy or an acyloxy, alkyloxy, alkenyloxy or alkinyloxy group, R1 is hydrogen or a group of formula STR2 R2 is hydrogen or a free or esterified carboxy group, Ra and Rb are hydrogen or methyl, p is zero or 1, R3 is a C1 -C2 alkylsulphonyl group, a phenyl or p-Cl phenyl, p-methylsulphonyl group or an acyl group; are useful as mucus regulating, antitussive and antibronchospastic agents.