13369-17-0Relevant articles and documents
Monocarboxylate transporter 1 inhibitors as potential anticancer agents
Gurrapu, Shirisha,Jonnalagadda, Sravan K.,Alam, Mohammad A.,Nelson, Grady L.,Sneve, Mary G.,Drewes, Lester R.,Mereddy, Venkatram R.
supporting information, p. 558 - 561 (2015/05/27)
Potent monocarboxylate transporter 1 inhibitors (MCT1) have been developed based on α-cyano-4-hydroxycinnamic acid template. Structure-activity relationship studies demonstrate that the introduction of p-N, N-dialkyl/diaryl, and o-methoxy groups into cyanocinnamic acid has maximal MCT1 inhibitory activity. Systemic toxicity studies in healthy ICR mice with few potent MCT1 inhibitors indicate normal body weight gains in treated animals. In vivo tumor growth inhibition studies in colorectal adenocarcinoma (WiDr cell line) in nude mice xenograft models establish that compound 27 exhibits single agent activity in inhibiting the tumor growth.
Ruthenium-catalyzed reductive amination of allylic alcohols
Sahli, Zeyneb,Sundararaju, Basker,Achard, Mathieu,Bruneau, Christian
supporting information; experimental part, p. 3964 - 3967 (2011/09/21)
Straighforward access to various saturated amines from allylic alcohols and isostructural mixture can now be achieved in the presence of arene ruthenium catalyst featuring phosphinesulfonate ligand and a hydrogen donor.
SYNTHESIS OF ALIPHATIC-AROMATIC AMINES IN THE PRESENCE OF THE COMPLEXES OF PALLADIUM IONS WITH POLYTRIMETHYLOLMELAMINE
Klyuev, M. V.
, p. 1741 - 1745 (2007/10/02)
The complexes of palladium ions with polytrimethylolmelamine effectively catalyze the hydrogenation amination of aldehydes with nitrobenzene under mild conditions (1 atm of hydrogen, 18-50 deg C).The intermediate products in the amination of aldehydes with nitro-, azo-, and azoxybenzene are phenylhydroxylamine, aniline, and the corresponding azomethine.
