135884-98-9Relevant articles and documents
New fMLF-OMe analogues containing constrained mimics of phenylalanine residue
Torrini, Ines,Mastropietro, Gaia,Zecchini, Giampiero Pagani,Paradisi, Mario Paglialunga,Lucente, Gino,Spisani, Susanna
, p. 170 - 176 (1998)
In the context of a research program aimed at elucidating the HCO-Met- Leu-Phe-OMe (fMLF-OMe) structural features which control interactions with the receptor in correspondence with the C-terminal residue, four different analogues of the native ligand have been synthesized and evaluated. Compounds 1-3 possess the general formula HCO-Met-Leu-Xaa-OMe with Xaa = N- benzylglycine, N-benzylphenylalanine, and α,α-dibenzylglycine, respectively. In the analogue 4 the constraint at the C-terminus has been obtained by incorporating a 2-oxopiperazine ring, made up of two phenylalanine residues, to replace the native C-terminal Phe residue. The consequences of the chemical modifications on the activity of the new analogues are discussed.
Conformational probes for elucidating the nature of substance P binding to the NK1 receptor: Initial efforts to map the Phe7-Phe8 region
Tong, Yunsong,Fobian, Yvette M.,Wu, Meiye,Boyd, Norman D.,Moeller, Kevin D.
, p. 1679 - 1682 (2007/10/03)
Three substance P analogs with conformation constraints in the Phe7- Phe8 region have been prepared in connection with an effort to differentiate two families of potential conformations for the binding of substance P to its NK1
