147128-77-6

• 

• Basic information

  1. Product Name: (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide
  2. Synonyms: (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide;4H-THIENO[2,3-B]THIOPYRAN-4-OL, 5,6-DIHYDRO-6-METHYL-, 7,7-DIOXIDE, (4S,6S);(4R,6S)-5,6-Dihydro-4-hydroxy-6-methylthieno[2,3-b]thiopyran-7,7-dioxide;(4R,6S)-5,6-Dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-ol 7,7-dioxide;5,6-Dihydro-(R,S)-4-acetoxy-(S)-6-methy1 -4H-thieno[2,3-b]thiopyran 7,7-dioxide;(4R,6S)-6-Methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-ol;(4R,6S)-5,6-dihydro-6-Methyl-4H-thieno[2,3-b]thiopyran-4-ol,7,7,-dioxide (4R,6S)-5,6-Dihydro-4-hydroxy-6-Methyl thieno2,3-b
  3. CAS NO:147128-77-6
  4. Molecular Formula: C8H10O3S2
  5. Molecular Weight: 218.296
  6. EINECS: 1533716-785-6
  7. Product Categories: N/A
  8. Mol File: 147128-77-6.mol
  9. Article Data: 8

• Chemical Properties

  1. Melting Point: 154-155 °C
  2. Boiling Point: 433.338 °C at 760 mmHg
  3. Flash Point: 215.876 °C
  4. Appearance: /
  5. Density: 1.462
  6. Vapor Pressure: 0mmHg at 25°C
  7. Refractive Index: 1.609
  8. Storage Temp.: Sealed in dry,Room Temperature
  9. Solubility: Chloroform (Sparingly), DMSO, Ethyl Acetate
  10. PKA: 13.06±0.40(Predicted)
  11. CAS DataBase Reference: (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide(CAS DataBase Reference)
  12. NIST Chemistry Reference: (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide(147128-77-6)
  13. EPA Substance Registry System: (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide(147128-77-6)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 147128-77-6(Hazardous Substances Data)

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• (4R,6S)-5,6-Dihydro-4-hydroxy-6-methylthieno[2,3-b]thiopyran-7,7-dioxide

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• Factory Supply (4R,6S)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-ol

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• (4R,6S)-5,6-Dihydro-4-hydroxy-6-methylthieno[2,3-b]thiopyran-7,7-dioxide

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• (4R,6S)-5,6-Dihydro-4-hydroxy-6-methylthieno[2,3-b]thiopyran-7,7-dioxide，Dorzolamide intermediate CAS NO.147128-77-6

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• (4R,6S)-5,6-Dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-ol-7,7-dioxide

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• (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide

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• C8H10O3S2 (4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide 147128-77-6

  Cas No: 147128-77-6

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147128-77-6 Usage

Uses

(4R,6S)-4H-Thieno[2,3-b]thiopyran-4-ol, 5,6-dihydro-6-methyl-,7,7-dioxide is an analog of topically-active carbonic anhydrase inhibitor MK-507 also commonly known as Dorzolamide (D535100).

Check Digit Verification of cas no

The CAS Registry Mumber 147128-77-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,1,2 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 147128-77:
(8*1)+(7*4)+(6*7)+(5*1)+(4*2)+(3*8)+(2*7)+(1*7)=136
136 % 10 = 6
So 147128-77-6 is a valid CAS Registry Number.

InChI:InChI=1/C8H10O3S2/c1-5-4-7(9)6-2-3-12-8(6)13(5,10)11/h2-3,5,7,9H,4H2,1H3/t5-,7+/m0/s1

147128-77-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	(4S,6S)-4H-Thieno[2,3-b]-thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:147128-77-6 SDS

147128-77-6Upstream product

• 147086-80-4 5,6-dihydro-(R)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 
• 148719-91-9 (S)-5,6-dihydro-6-methylthieno<2,3-b>thiopyran-4-one 7,7-dioxide 
• 108-05-4 vinyl acetate 
• 147086-81-5 4-hydroxy-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran 7,7-dioxide 
• 894793-33-0 5,6-dihydro-4-oxo-(S)-6-methyl-thieno[2,3-b]thiopyran-7,7-dioxide 
• 148810-82-6 5,6-dihydro-(R)-4-acetoxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide 
• 133359-80-5 (S)-3-(thien-2-ylthio)butyric acid 
• 147086-79-1 (S)-5,6-dihydro-6-methylthieno<2,3-b>thiopyran-4-one 
• 133359-79-2 methyl (S)-3-(thiophen-2-ylthio)butyrate 

147128-77-6Downstream Products

• 1197375-13-5 (4S,6R)-4-hydroxy-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran 7,7-dioxide 
• 148810-82-6 5,6-dihydro-(R)-4-acetoxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide 
• 1227941-26-5 5,6-dihydro-4H-4-acetyl amino-6-methylthieno[2,3-b]thiopyran-7,7-dioxide 
• 147086-83-7 N-(5,6-dihydro-(S)-6-methyl-4H-thieno<2,3-b>thiopyran-(S)-4-yl)acetamide 7,7-dioxide 
• 147086-83-7 N-(5,6-dihydro-(S)-6-methyl-4H-thieno<2,3-b>thiopyran-4-yl)acetamide 7,7-dioxide 
• 148810-82-6 5,6-dihydro-(R,S)-4-acetoxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide 

147128-77-6Relevant articles and documents

ASYMMETRIC REDUCTION PROCESS

-

Page/Page column 13; 14, (2012/09/22)

The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SO2 and R4 is hydrogen or an SO2NH2 group, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof.

Applying lipase catalysis to access the enantiomers of dorzolamide intermediates

Turcu, Mihaela C.,Rantapaju, Maria,Kanerva, Liisa T.

experimental part, p. 5594 - 5600 (2010/03/01)

The kinetic resolution of three dorzolamide intermediates has been studied in the presence of Burkholderia cepacia li-pase in organic solvents. All the stereoisomers of 6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-ol were prepared starting from the ra

ENZYMATIC ASYMMETRIC REDUCTION PROCESS TO PRODUCE 4 H-THIENO(2,3-6)THIO PYRANE DERIVATIVES

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Page 4, (2008/06/13)

PCT No. PCT/GB93/01776 Sec. 371 Date Feb. 28, 1995 Sec. 102(e) Date Feb. 28, 1995 PCT Filed Aug. 20, 1993 PCT Pub. No. WO94/05802 PCT Pub. Date Mar. 17, 1994A compound of formula in which X is hydrogen or a group of formula -SO2NH2 is reduced to the trans (4S,6S) form of the corresponding alcohol by an enzyme reduction system.

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