147086-83-7

Usage

InChI:InChI=1/C10H13NO3S2/c1-6-5-9(11-7(2)12)8-3-4-15-10(8)16(6,13)14/h3-4,6,9H,5H2,1-2H3,(H,11,12)/t6-,9-/m0/s1

Upstream product

• 147086-84-8 (S)-6-Methyl-6H-thieno[2,3-b]thiopyran 7,7-dioxide 
• 75-05-8 acetonitrile 
• 1034290-08-8 5,6-dihydro-(R,S)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide 
• 148810-82-6 5,6-dihydro-(R,S)-4-acetoxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide 
• 60-35-5 acetamide 
• 147086-81-5 (4R,6S)-4-hydroxy-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran 7,7-dioxide 
• 147086-81-5 5,6-dihydro-4-hydroxy-(S)-6-methyl-thieno[2,3-b]thiopyran-7,7-dioxide 
• 133359-79-2 methyl (S)-3-(thiophen-2-ylthio)butyrate 
• 133359-80-5 (S)-3-(thien-2-ylthio)butyric acid 
• 147086-80-4 5,6-dihydro-(R)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 
• 147086-79-1 (S)-5,6-dihydro-6-methylthieno<2,3-b>thiopyran-4-one 

Downstream Products

• 403848-01-1 trans-4-(N-ethylamino)-5,6-dihydro-6-methyl-4H-thien-(2,3-b)-thiopyran-7,7-dioxide 

Relevant academic research and scientific papers

Key intermediate of dorzolamide hydrochloride and synthesis method thereof

The invention discloses a synthesis method of a key intermediate of dorzolamide hydrochloride. The method comprises the following steps: sequentially adding a compound II, acetamide, an acid binding agent and a phase transfer catalyst to an organic solven

PROCESS FOR PREPARING DORZOLAMIDE HYDROCHLORIDE AND ITS INTERMEDIATE

The present invention relates to an improved process for the preparation of (4S,6S)-4- (ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide hydrochloride ("Dorzolamide hydrochloride") having formula 1. Dorzolamide hydrochloride is prepared by the process of the present invention with high chemical and diastereomeric purity. The present invention also relates to novel intermediate of the formula 20 and a process for its preparation. Dorzolamide hydrochloride is useful in the treatment of ocular hypertension by inhibiting carbonic anhydrase enzyme.