151004-93-2

• 

• Basic information

  1. Product Name: (R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID
  2. Synonyms: (R)-1,2,3,4-TETRAHYDRO-1-ISOQUINOLINE CARBOXYLIC ACID;(R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID;1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-, (1R)-;(1R)-1,2,3,4-tetrahydro-1-Isoquinolinecarboxylic acid
  3. CAS NO:151004-93-2
  4. Molecular Formula: C₁₀H₁₁NO₂
  5. Molecular Weight: 177.2
  6. EINECS: N/A
  7. Product Categories: pharmacetical
  8. Mol File: 151004-93-2.mol
  9. Article Data: 4

• Chemical Properties

  1. Melting Point: 239-240 °C(Solv: water (7732-18-5); acetone (67-64-1))
  2. Boiling Point: 370.7°Cat760mmHg
  3. Flash Point: 178°C
  4. Appearance: /
  5. Density: 1.225g/cm³
  6. Vapor Pressure: 3.77E-06mmHg at 25°C
  7. Refractive Index: 1.576
  8. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
  9. Solubility: N/A
  10. PKA: 1.84±0.20(Predicted)
  11. CAS DataBase Reference: (R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID(CAS DataBase Reference)
  12. NIST Chemistry Reference: (R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID(151004-93-2)
  13. EPA Substance Registry System: (R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID(151004-93-2)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 151004-93-2(Hazardous Substances Data)

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• SDS
• Upstream product
• Downstream Products
• Article

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• (R)-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXYLIC ACID

  Cas No: 151004-93-2

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• (R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID CAS:151004-93-2

  Cas No: 151004-93-2

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• 1-Isoquinolinecarboxylicacid, 1,2,3,4-tetrahydro-, (1R)-

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• Hangzhou J&H Chemical Co., Ltd.
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• (1R)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid CAS NO.151004-93-2

  Cas No: 151004-93-2

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• Hangzhou Huarong Pharm Co., Ltd.
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• (R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID

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• (R)-1,2,3,4-Tetrahydro-1-isoquinolinecarboxylic acid

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• Suzhou Health Chemicals Co., Ltd.
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• (R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID

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• Henan Allgreen Chemical Co.,Ltd
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• 1-Isoquinolinecarboxylicacid, 1,2,3,4-tetrahydro-, (1R)-

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151004-93-2 Usage

General Description

The chemical (R)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid is a compound belonging to the class of isoquinolines. It is a carboxylic acid derivative with a tetrahydroisoquinoline structure. (R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID has potential biological and pharmacological activities and is often used as a building block in organic synthesis and medicinal chemistry. It has been studied for its potential therapeutic effects in various diseases, including neurological disorders and cancer. Further research is needed to fully understand its properties and potential applications in medicine and industry.

Check Digit Verification of cas no

The CAS Registry Mumber 151004-93-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,0,0 and 4 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 151004-93:
(8*1)+(7*5)+(6*1)+(5*0)+(4*0)+(3*4)+(2*9)+(1*3)=82
82 % 10 = 2
So 151004-93-2 is a valid CAS Registry Number.

InChI:InChI=1/C10H11NO2/c12-10(13)9-8-4-2-1-3-7(8)5-6-11-9/h1-4,9,11H,5-6H2,(H,12,13)/t9-/m1/s1

151004-93-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	(R)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid

1.2 Other means of identification

Product number	-
Other names	(1R)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:151004-93-2 SDS

151004-93-2Upstream product

• 41034-52-0 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 486-73-7 1-isoquinolinecarboxylic acid 
• 106181-28-6 ethyl (+/-)-1,2,3,4-tetrahydroisoquinoline-1-carboxylate 

151004-93-2Downstream Products

• 765915-89-7 N-[(R)-1-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide 
• 135526-78-2 (-)-Praziquantel 
• 954239-58-8 (1R)-1-hydroxymethyl-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline 
• 832711-65-6 N-(benzyloxycarbonyl)-1(R)-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline 
• 151004-88-5 (R)-N-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisiquinoline-1-carboxylic acid 
• 151004-96-5 (1R)-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 

151004-93-2Relevant articles and documents

Directed (R)- or (S)-selective dynamic kinetic enzymatic hydrolysis of 1,2,3,4-tetrahydroisoquinoline-1-carboxylic esters

Paal, Tihamer A.,Liljeblad, Arto,Kanerva, Liisa T.,Forro, Eniko,Fueloep, Ferenc

, p. 5269 - 5276 (2008)

The first synthesis of both enantiomers of 6,7-dimethoxy-1,2,3,4- tetrahydroisoquinoline-1-carboxylic acid was accomplished through dynamic kinetic resolution in procedures based on CAL-B- or subtilisin Carlsberg-catalysed enantioselective hydrolysis of the corresponding ethyl esters in aqueous NH4OAc buffer at pH 8.5. The products were obtained with high enantiopurity (92-93%ee) in good yields (85-92%). (R)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid was obtained with high enantiopurity (98%ee) and in good yield (85%) in a CAL-B-catalysed process, under similar conditions. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Lipase-catalyzed kinetic and dynamic kinetic resolution of 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

Paal, Tihamer A.,Forro, Eniko,Liljeblad, Arto,Kanerva, Liisa T.,Fueloep, Ferenc

, p. 1428 - 1433 (2008/02/10)

A dynamic kinetic resolution method for the preparation of enantiopure 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (R)-2 was developed involving the CAL-B-catalyzed enantioselective hydrolysis of the corresponding ethyl ester (±)-1 in toluene/acetonitrile (4:1) containing 1 equiv of added water and 0.25 equiv of dipropylamine. This method allowed the preparation of (R)-2 (ee = 96%) with 80% isolated yield. The kinetic resolution of (±)-1 in diisopropyl ether at 3 °C afforded both enantiomers with ee ≥92%.

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