41034-52-0

Basic information

• Product Name: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID
• Synonyms: BIM-0037743.P001;MLS000070678;SBB003410;SMR000011474;TIMTEC-BB SBB000197;1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID;1,2,3,4-tetrahydroisoquinoline carboxylic acid;1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-
• CAS NO: 41034-52-0
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• Product Categories: pharmacetical
• Mol File: 41034-52-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 268-270℃
• Boiling Point: 370.7 °C at 760 mmHg
• Flash Point: 178 °C
• Appearance: /
• Density: 1.225 g/cm³
• Vapor Pressure: 3.77E-06mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID(41034-52-0)
• EPA Substance Registry System: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID(41034-52-0)

Safety Data

• Hazardous Substances Data: 41034-52-0(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

InChI:InChI=1/C10H11NO2/c12-10(13)9-8-4-2-1-3-7(8)5-6-11-9/h1-4,9,11H,5-6H2,(H,12,13)

Upstream product

• 486-73-7 1-isoquinolinecarboxylic acid 
• 844-25-7 2-benzoyl-1-cyano-1,2-dihydroisoquinoline 

Downstream Products

• 111157-56-3 2,3,3aα,4β,6,11,11aα,11bα-octahydro-2-methyl-4-(2-phenylethyl)-1H-pyrrolo<3',4':3,4>pyrrolo<1,2-b>isoquinoline-1,3-dione 
• 111157-56-3 2,3,3aα,4α,6,11,11aβ,11bα-octahydro-2-methyl-4-(2-phenylethyl)-1H-pyrrolo<3',4':3,4>pyrrolo<1,2-b>isoquinoline-1,3-dione 
• 111016-18-3 2,3,3aα,4α,6,11,11aβ,11α-octahydro-2-methyl-4-(4-nitrophenyl)-1H-pyrrolo<3',4':3,4>pyrrolo<1,2-b>isoquinoline-1,3-dione 
• 111016-18-3 2,3,3aα,4β,6,11,11aβ,11bα-octahydro-2-methyl-4-(4-nitrophenyl)-1H-pyrrolo<3',4':3,4>pyrrrolo<1,2-b>isoquinoline-1,3-dione 
• 111016-18-3 2,3,3aα,4β,6,11,11aα,11bα-octahydro-2-methyl-4-(4-nitrophenyl)-1H-pyrrolo<3',4':3,4>pyrrolo<1,2-b>isoquinoline-1,3-dione 
• 111016-17-2 2,3,3aα,4α,6,11,11aβ,11bα-octahydro-4-(4-dimethylaminophenyl)-2-methyl-1H-pyrrolo<3',4':3,4>pyrrolo<1,2-b>isoquinoline-1,3-dione 
• 111016-17-2 2,3,3aα,4β,6,11,11aα,11bα-octahydro-4-(4-dimethylaminophenyl)-2-methyl-1H-pyrrolo<3',4':3,4>pyrrolo<1,2-b>isoquinoline-1,3-dione 
• 32909-74-3 1-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline 
• 35264-05-2 2-((tert-butoxycarbonyl)amino)-2-cyclohexylacetic acid 
• 166591-85-1 (±)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 92932-75-7 2-[(3-mercapto)-1-oxopropyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 151004-96-5 (1R)-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 954239-58-8 (1R)-1-hydroxymethyl-2-[(tert-butyl) oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline 
• 135526-78-2 (-)-Praziquantel 

Relevant articles and documents

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Lipase-catalyzed kinetic and dynamic kinetic resolution of 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

A dynamic kinetic resolution method for the preparation of enantiopure 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (R)-2 was developed involving the CAL-B-catalyzed enantioselective hydrolysis of the corresponding ethyl ester (±)-1 in toluene/acetonitrile (4:1) containing 1 equiv of added water and 0.25 equiv of dipropylamine. This method allowed the preparation of (R)-2 (ee = 96%) with 80% isolated yield. The kinetic resolution of (±)-1 in diisopropyl ether at 3 °C afforded both enantiomers with ee ≥92%.

SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS

The invention relates to compounds of formula (I), wherein R1, R2, R3, R4, A, n and L have the significances indicated in the description. The use of the inventive compounds in the form of drags for preventing and/or treating diseases in which progression an active reinforced matrix-metalloproteinases take part is also disclosed.