154924-17-1Relevant articles and documents
Synthesis and luminescence properties of near-infrared N-heterocyclic luciferin analogues for in vivo optical imaging
Saito, Ryohei,Kuchimaru, Takahiro,Higashi, Shoko,Lu, Shijia W.,Kiyama, Masahiro,Iwano, Satoshi,Obata, Rika,Hirano, Takashi,Kizaka-Kondoh, Shinae,Maki, Shojiro A.
, p. 608 - 618 (2019/04/05)
As a means of achieving highly sensitive bioluminescence imaging of deep tissues utilizing the firefly luciferin-luciferase (L-L) reaction, we previously reported a luciferin analogue, AkaLumine, which exhibits high cell-permeability and emits near-infrar
NOVEL HETEROCYCLIC COMPOUNDS AND SALTS THEREOF, AND LUMINESCENT SUBSTRATE COMPOSITIONS
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Paragraph 0052; 0053, (2016/10/07)
PROBLEM TO BE SOLVED: To provide novel compounds excellent in solubility in a buffer solution having a near-neutral pH and available as luminescent substrates in firefly bioluminescence systems. SOLUTION: The present invention provides heterocyclic compou
Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer
Jia, Hong,Dai, Guangxiu,Weng, Jianyang,Zhang, Zhulin,Wang, Qing,Zhou, Feng,Jiao, Longxian,Cui, Yumin,Ren, Yongxin,Fan, Shiming,Zhou, Jinghong,Qing, Weiguo,Gu, Yi,Wang, Jian,Sai, Yang,Su, Weiguo
supporting information, p. 7577 - 7589 (2014/12/11)
HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.