15992-83-3Relevant articles and documents
A highly selective fluorescent sensor for Cd2+ based on a new diarylethene with a 1,8-naphthyridine unit
Zhang, Xiaoxia,Wang, Renjie,Fan, Congbin,Liu, Gang,Pu, Shouzhi
, p. 208 - 217 (2017)
A new asymmetrical photochromic diarylethene has been synthesized by using 1,8-naphthyridine as a functional group and perfluorodiarylethene as photoswitching unit via a peptide bond linkage, and its molecular structure was characterized by single crystal X-ray diffraction analysis. The compound exhibited favorable photochromism upon irradiation with UV/vis light, and its fluorescent behaviour could be efficiently modulated by light, base/acid, and metal ion in THF. The deprotonated derivative of the diarylethene also showed good photochromism, and displayed remarkable “turn-on” fluorescence response during photocyclization process. Furthermore, the diarylethene was highly selective toward Cd2+ with an obvious fluorescent color change from dark to bright green in THF. Finally, a logic circuit was fabricated with four inputs of the combinational stimuli of UV/vis and Cd2+/EDTA, and one output of fluorescence intensity.
Chichibabin Amination of 1,X-Naphthyridines. Nuclear Magnetic Resonance Studies on the ? Adducts of Heterocyclic Systems with Nucleophiles
Haak, Henk J. W. van den,Plas, Henk C. van der,Veldhuizen, Beb van
, p. 2134 - 2137 (1981)
In the amination of 1,X-naphthyridines with potassium amide in liquid ammonia at about -35 to -40 deg C the initial adduct formation is charge controlled.Thus, at these temperatures the site with the lowest electron density is most susceptible for amide attack (C-2 in 1,5-naphthyridine, C-2 in 1,6-naphthyridine, C-2 and C-8 in 1,7-naphthyridine, and C-2 in 1,8-naphthyridine), as proven by NMR spectroscopy.When the temperature was raised to about 10 deg C, the site of addition has been found to change for 1,5- and 1,7-naphthyridine (NMR spectroscopy): from C-2 to C-4 in 1,5-naphthyridine and from C-2 and C-8 to C-8 only in 1,7-naphthyridine.In case of 1,6- and 1,8-naphthyridines no change was observed.Thus, the amination at about 10 deg C is a process which is thermodynamically controlled.The several factors which contribute to the stability of these addition products have been discussed.It has been found that the anionic ? adducts 2(4,8)-aminodihydro-1,X-naphthyridinides can be easily oxidized with potassium permanganate into their corresponding 2(4,8)-amino-1,X-naphthyridines.
Reversible Stereoselective Folding/Unfolding Fueled by the Interplay of Photoisomerism and Hydrogen Bonding
Opie, Christopher R.,Kumagai, Naoya,Shibasaki, Masakatsu
supporting information, p. 3349 - 3353 (2017/03/17)
A linear molecular architecture equipped with complementary three-fold hydrogen-bonding units embedded with a photoswitchable trans-tetrafluoroazobenzene moiety was synthesized. The transto cis photoisomerism of the azobenzene unit induced drastic changes
TETRAHYDRO[1,8]NAPHTHYRIDINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF ROR? AND THE TREATMENT OF DISEASE
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Paragraph 00198, (2013/12/03)
The invention provides tetrahydro[1,8]naphthyridine and related compounds, pharmaceutical compositions, methods of promoting ROR? activity, increasing the amount of IL-17 in a subject, and treating cancer using such tetrahydro[1,8]naphthyridine and relate
