17469-89-5Relevant articles and documents
Iheyamides A-C, Antitrypanosomal Linear Peptides Isolated from a Marine Dapis sp. Cyanobacterium
Kurisawa, Naoaki,Iwasaki, Arihiro,Jeelani, Ghulam,Nozaki, Tomoyoshi,Suenaga, Kiyotake
, p. 1684 - 1690 (2020/06/08)
Iheyamides A (1), B (2), and C (3), new linear peptides, were isolated from a marine Dapis sp. cyanobacterium. Their structures were elucidated by spectroscopic analyses and degradation reactions. Iheyamide A (1) showed moderate antitrypanosomal activities against Trypanosoma brucei rhodesiense and Trypanosoma brucei brucei (IC50 = 1.5 μM), but the other two analogues, iheyamides B (2) and C (3), did not (IC50 > 20 μM, respectively). The structure-activity relationship clarified that an isopropyl-O-Me-pyrrolinone moiety was necessary for the antitrypanosomal activity. Furthermore, the cytotoxicity of 1 against normal human cells, WI-38, was 10 times weaker than its antitrypanosomal activity (IC50 = 18 μM).
Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia
Bitchi, Michel Boni,Magid, Abdulmagid Alabdul,Kabran, Faustin Aka,Yao-Kouassi, Philomène Akoua,Harakat, Dominique,Morjani, Hamid,Tonzibo, Félix Zanahi,Voutquenne-Nazabadioko, Laurence
, (2019/08/12)
Heisteria parvifolia Sm. is prescribed in traditional medecine against numerous diseases in C?te d'Ivoire. Due to the shortcoming in scientifical knowledge of use of this species, our investigations revealed five undescribed cyclopeptide alkaloids added to one known derivative namely anorldianine. These compounds were elucidated by 1D and 2D-NMR experiments and comparison with literature data, and confirmed by HR-ESI-MS. Cytotoxic activity evaluation of these compounds against the chronic myeloid leukemia (K565) cell line exhibited an antiproliferative activity with cell growth inhibition from 13% to 46%.
Palladium Nanoparticle Loaded Bifunctional Silica Hybrid Material: Preparation and Applications as Catalyst in Hydrogenation Reactions
Surmiak, Sabrina K.,Doerenkamp, Carsten,Selter, Philipp,Peterlechner, Martin,Sch?fer, Andreas H.,Eckert, Hellmut,Studer, Armido
supporting information, p. 6019 - 6028 (2017/05/05)
Bifunctional mesoporous silica was prepared by co-condensation of tetraethyl orthosilicate (TEOS) with functionalized organosilanes containing azides or alkoxyamines. Orthogonal functional groups at the particles were selectively addressed in subsequent chemical modifications through “click”-chemistry (“click to ligand” strategy) and radical nitroxide exchange. Palladation with PdCl2 delivered Pd nanoparticle-loaded silica material bearing sulfoxides and additional aminoamides as stabilizing ligands by means of in situ reduction of the PdII-salt. These functional particles were successfully applied to the hydrogenation of alkynes and alkenes. Aldehyde hydrodeoxygenation and benzyl ether cleavage were achieved with these hybrid catalysts under mild conditions. Particles were analyzed by IR, TEM/STEM, EDX, and solid-state NMR spectroscopy.
