178488-37-4Relevant articles and documents
Microwave-assisted synthesis of 3-formyl substituted imidazo[1,2-a]pyridines
Kusy, Damian,Maniukiewicz, Waldemar,B?a?ewska, Katarzyna M.
supporting information, (2019/10/16)
An efficient, metal-free method for the synthesis of 3-formyl imidazo[1,2-a]pyridines is reported. The method utilises commercially available substrates and features a broad substrate scope. The intermediate enamine was isolated and a plausible reaction mechanism proposed.
Benzimidazolone as potent chymase inhibitor: Modulation of reactive metabolite formation in the hydrophobic (P1) region
Lo, Ho Yin,Nemoto, Peter A.,Kim, Jin Mi,Hao, Ming-Hong,Qian, Kevin C.,Farrow, Neil A.,Albaugh, Daniel R.,Fowler, Danielle M.,Schneiderman, Richard D.,Michael August,Martin, Leslie,Hill-Drzewi, Melissa,Pullen, Steven S.,Takahashi, Hidenori,De Lombaert, Stephane
scheme or table, p. 4533 - 4539 (2011/09/12)
A new class of chymase inhibitor featuring a benzimidazolone core with an acid side chain and a P1 hydrophobic moiety is described. Incubation of the lead compound with GSH resulted in the formation of a GSH conjugate on the benzothiophene P1 moiety. Replacement of the benzothiophene with different heterocyclic systems such as indoles and benzoisothiazole is feasible. Among the P1 replacements, benzoisothiazole prevents the formation of GSH conjugate and an in silico analysis of oxidative potentials agreed with the experimental outcome.
Reactions with N-chlorosuccinimide of various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position
Ikemoto, Tomomi,Wakimasu, Mitsuhiro
, p. 99 - 108 (2007/10/03)
Chlorination reactions using N-chlorosuccinimide (NCS) was investigated for various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position. These reactions showed different results, and by examining these, we proposed a reaction mechanism via the appropriate 3-halogenoimidazo[1,2-a]pyridium compounds as the reaction intermediates.