19183-05-2Relevant articles and documents
(E)-N-Aryl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetohydrazonoyl cyanides as tubulin polymerization inhibitors: Structure-based bioisosterism design, synthesis, biological evaluation, molecular docking and in silico ADME prediction
Wang, Guangcheng,Peng, Zhiyun,Peng, Shanshan,Qiu, Jie,Li, Yongjun,Lan, Yanyu
supporting information, p. 3350 - 3355 (2018/09/12)
A series of (E)-N-Aryl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetohydrazonoyl cyanides have been synthesized and evaluated for their anticancer activity in human hepatocellular liver carcinoma HepG2 and breast adenocarcinoma MCF-7 cell lines. Among all the test
Synthesis method of substituted phenylhydrazine and salt thereof
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Paragraph 0133; 0134, (2017/08/29)
The invention relates to a novel synthesis method of substituted phenylhydrazine and salt thereof. A substituted phenyl diazene compound is reduced to generate the substituted phenylhydrazine; a reducing agent B is selected from one or several of a catalytic hydrogenating system, formic acid, formate and formic acid ester compound; the obtained substituted phenylhydrazine can be further acidified to prepare the substituted phenylhydrazine salt which is easily stored and transported. The synthesis method has the advantages that the yield rate is high, the cost is low, the reaction time is short, the technology operation and post-treatment are simple, and the amount of waste water, waste gas and waste residue is fewer; the component of the produced waste water is single, the recycling is convenient, the treatment cost is low, and the green chemical requirement is met; the synthesis method of the substituted phenylhydrazine is more suitable for the large-scale industrialized production.
Parallel synthesis of "Click" chalcones as antitubulin agents
Utsintong, Maleeruk,Massarotti, Alberto,Caldarelli, Antonio,Theeramunkong, Sewan
, p. 510 - 516 (2013/07/28)
It has been shown that some chalcones are able to inhibit tubulin polymerization, giving cytotoxicity and destruction of tumoral vasculature. A library of 180 novel chalcone analogs has been synthesized via click chemistry and screened for their cytotoxic