1939-24-8 Usage
Description
N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE, with the molecular formula C14H10F3NO, is a white solid chemical compound that serves as a crucial building block in the synthesis of pharmaceutical and agrochemical compounds. Its structure features a trifluoromethyl group, which is recognized for its potent electron-withdrawing properties, thereby enhancing the compound's potential in creating bioactive molecules. This versatile and reactive nature positions N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE as an indispensable tool in medicinal chemistry, particularly for developing new drugs in the realms of cancer treatments and antiviral agents.
Uses
Used in Pharmaceutical Industry:
N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE is utilized as a key intermediate in the synthesis of various drugs, primarily due to its ability to enhance the bioactivity and pharmacokinetic properties of the final drug products. Its electron-withdrawing trifluoromethyl group contributes to the compound's overall effectiveness, making it a sought-after component in drug development.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE is employed as a valuable research tool for the development of innovative cancer treatments and antiviral agents. Its unique structural features and reactivity allow for the creation of new drug candidates with improved therapeutic profiles and targeted mechanisms of action.
Used in Agrochemical Compounds:
N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE also finds application in the agrochemical industry, where it is used as a component in the development of pesticides and other agricultural chemicals. Its electron-withdrawing properties can enhance the effectiveness of these compounds, leading to improved crop protection and yield.
Check Digit Verification of cas no
The CAS Registry Mumber 1939-24-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,3 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1939-24:
(6*1)+(5*9)+(4*3)+(3*9)+(2*2)+(1*4)=98
98 % 10 = 8
So 1939-24-8 is a valid CAS Registry Number.
1939-24-8Relevant articles and documents
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Benkeser,Severson
, p. 3838 (1949)
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An Environmentally Benign, Catalyst-Free N?C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides
Kumar, Vishal,Dhawan, Sanjeev,Girase, Pankaj Sanjay,Singh, Parvesh,Karpoormath, Rajshekhar
, p. 5627 - 5639 (2021/11/11)
Herein, we report an operationally simple, cheap, and catalyst-free method for the transamidation of a diverse range of unactivated amides furnishing the desired products in excellent yields. This protocol is environmentally friendly and operates under extremely mild conditions without using any promoter or additives. Significantly, this strategy has been implied in the chemoselective synthesis of a pharmaceutical molecule, paracetamol, on a gram-scale with excellent yield. We anticipate that this universally applicable strategy will be of great interest in drug discovery, biochemistry, and organic synthesis.
Chromium-catalyzed ligand-free amidation of esters with anilines
Chen, Changpeng,Ling, Liang,Luo, Meiming,Zeng, Xiaoming
supporting information, p. 762 - 766 (2021/04/14)
Amides are important structural motifs in pharmaceutical and agrochemical chemistry because of the intriguing biological active properties. We report here the amidation of commercially available esters with anilines that was promoted by low-cost and air-stable chromium(III) pre-catalyst combined with magnesium, providing access to amides. This reaction occurs without the use of external ligands in a simple operation. Mechanistic studies indicate that a reactive aminated Cr species responsible for the amidation can be considered, which may be formed by reaction of low-valent Cr with aniline followed by reduction with hydrogen evolution.
