195138-76-2Relevant articles and documents
Enantioselective synthesis of 2,3-disubstituted piperidines from (S)- methylpyroglutamate
Calvez, Olivier,Chiaroni, Angele,Langlois, Nicole
, p. 9447 - 9450 (2007/10/03)
N-methoxy-N-methylamide derived from (S)-methylpyroglutamate was prepared in good yield and allowed the addition of Grignard reagents. Erythro (2S)-1-benzyl-2-hydroxybenzyl pyrrolidine obtained by this way was converted into (2S,3R)-1-benzyl-3-hydroxy-2-phenylpiperidine and its chloro analog.