195525-52-1Relevant articles and documents
Pyrrolidinones derived from (S)-pyroglutamic acid. Part 3. β-Aminopyrrolidinones
Chan,Cottrell,Moloney
, p. 2997 - 3006 (2007/10/03)
The conjugate addition of activated nitrogen nucleophiles, such as hydroxylamine and hydrazine derivatives, to α, β-unsaturated bicyclic lactam 1a gave the corresponding β-amino products 9a-g in good yield and excellent diastereo- selectivity. These products can be manipulated to afford enantiopure β-aminopyrrolidinones of potential application as conformationally-constrained, substituted glutamate templates of well-defined stereochemistry.