195967-10-3Relevant articles and documents
Amphiphilic pentaazamacrocyclic manganese superoxide dismutase mimetics
Lieb, Dominik,Kenkell, Isabell,Miljkovic, Jan Lj.,Moldenhauer, Daniel,Weber, Nadine,Filipovic, Milos R.,Groehn, Franziska,Ivanovic-Burmazovic, Ivana
, p. 1009 - 1020 (2014)
Five newly functionalized pentaazamacrocyclic manganese complexes, with variable lengths and amounts of the aliphatic groups (three compounds with one linear chain containing 12, 16, and 22 carbon atoms, i.e., MnL1, MnL2, and MnL3, respectively, as well as two compounds containing two C12 and C16 chains, MnL4 and MnL5, respectively) that are derivatives of the known SOD mimetic, Mn(Me2-Pyane), have been synthesized. These amphiphilic complexes were characterized by the ESI mass spectrometry, potentiometric titrations, light scattering, cyclic voltammetry, and direct stopped-flow determination of their SOD activity at pH 8.1 and 7.4 (in phosphate and HEPES buffers). The formation of supramolecular aggregates that predominantly exist in the solution as a defined micellar/nanostructure assembly, with an average 400 nm size, has been demonstrated for MnL1. The biological effects of the selected complexes (MnL1 and MnL2) on the superoxide level in cytosol and mitochondria have been tested, as well as their effects on the prevention of the lipid peroxidation induced by paraquat. Advantages and disadvantages of the lipophilic pentaazamacrocyclic manganese SOD mimetics in comparison to the corresponding nonsubstituted SOD active complex have been discussed.
Synthetic Access to Derivatized Mn-Pyane as a Redox-modulated Pool of SODm
Scheitler, Andreas,Friedel, Felix,Puchta, Ralph,Dücker-Benfer, Carlos,Ivanovi?-Burmazovi?, Ivana
, p. 713 - 718 (2018)
In this work, four derivatives of the pentaazamacrocyclic Mn-pyane [pyane = trans-2,13-dimethyl-3,6,9,12,18-pentaazabicyclo[12.3.1]-octadeca-1(18),14,16-triene] complex were synthesized and characterized, carrying small substituents at the pyridine ring that allow fine-tuning of the manganese centered redox potential, without significant change to the overall complex arrangement that is crucial for a correct comparison regarding their superoxide dismutase mimetic (SODm) capabilities. The crystal structure of the seven-coordinate OMe-substituted Mn-pyane complex was obtained. The synthesized complexes will serve for future investigations related to an effect of complex redox potentials on their mechanistic behavior within SOD catalysis.
Ruthenium(II) sensitizers with heteroleptic tridentate chelates for dye-sensitized solar cells
Chou, Chun-Cheng,Wu, Kuan-Lin,Chi, Yun,Hu, Wei-Ping,Yu, Shuchun Joyce,Lee, Gene-Hsiang,Lin, Chi-Li,Chou, Pi-Tai
, p. 2054 - 2058 (2011/04/23)
Two new for Ru: Unprecedented RuII sensitizers are coordinated by two tridentate ligands, a tricarboxyterpyridine, and a dianionic bis(pyrazolyl)pyridine derivative with an extended π-conjugated auxochrome (see picture, Rumagenta, Nblue, Ored, Fgreen, Syellow, Cgray). This new generation of thiocyanate-free RuII sensitizers offers solar conversion efficiency in dye-sensitized solar cells up to I·=10.7 %.
