196597-81-6

• 

• Basic information

  1. Product Name: (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine
  2. Synonyms: (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine;(8S)-;2H-Indeno[5;4-b]furan-8-ethanaMine;8-tetrahydro-;2H-Indeno[5,4-b]furan-8-ethanaMine, 1,6,7,8-tetrahydro-, (8S)-;(S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-9-yl)ethylaMine;(S)-2-(1,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)ethanaMine
  3. CAS NO:196597-81-6
  4. Molecular Formula: C13H17NO
  5. Molecular Weight: 203.283
  6. EINECS: 1592732-453-0
  7. Product Categories: Ramelteon
  8. Mol File: 196597-81-6.mol
  9. Article Data: 21

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 329.637 °C at 760 mmHg
  3. Flash Point: 156.769 °C
  4. Appearance: /
  5. Density: 1.129
  6. Vapor Pressure: 0mmHg at 25°C
  7. Refractive Index: 1.587
  8. Storage Temp.: 2-8°C
  9. Solubility: N/A
  10. PKA: 10.27±0.10(Predicted)
  11. CAS DataBase Reference: (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine(CAS DataBase Reference)
  12. NIST Chemistry Reference: (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine(196597-81-6)
  13. EPA Substance Registry System: (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine(196597-81-6)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 196597-81-6(Hazardous Substances Data)

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• (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine

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• High purity (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine CAS No.:196597-81-6

  Cas No: 196597-81-6

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• Ality Chemical Corporation
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• High Quality 99% 2H-Indeno[5,4-b]furan-8-ethanamine,1,6,7,8-tetrahydro-, (8S)- 196597-81-6 ISO Manufacturer

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• (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)-ethylamine

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• (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine CAS 196597-81-6

  Cas No: 196597-81-6

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• (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl) ethylamine

  Cas No: 196597-81-6

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• 2H-Indeno[5,4-b]furan-8-ethanamine,1,6,7,8-tetrahydro-, (8S)- 196597-81-6

  Cas No: 196597-81-6

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196597-81-6 Usage

General Description

(S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine, also known as "THIFEA," is a chemical compound with the molecular formula C15H21NO that belongs to the class of amines. It is a chiral compound, meaning that it has a non-superimposable mirror image, and the (S)-enantiomer is the active form. THIFEA has been studied for its potential pharmacological effects, including its potential as a ligand for certain receptors and its possible use in the development of pharmaceutical drugs. It is important to note that further research is needed to fully understand the properties and potential applications of this chemical compound.

Check Digit Verification of cas no

The CAS Registry Mumber 196597-81-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,6,5,9 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 196597-81:
(8*1)+(7*9)+(6*6)+(5*5)+(4*9)+(3*7)+(2*8)+(1*1)=206
206 % 10 = 6
So 196597-81-6 is a valid CAS Registry Number.

InChI:InChI=1/C13H17NO/c14-7-5-10-2-1-9-3-4-12-11(13(9)10)6-8-15-12/h3-4,10H,1-2,5-8,14H2/t10-/m0/s1

196597-81-6Upstream product

• 196597-76-9 ethyl 3-(6,7-dibromo-2,3-dihydrobenzofuran-5-yl) propionic acid 
• 196597-75-8 ethyl 3-(6,7-dibromo-2,3-dihydro-1-benzofuran-5-yl)propanoate 
• 221530-44-5 2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile 
• 221530-38-7 (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)acetamide 
• 1361396-60-2 (E)-3-(2,3-dihydrobenzofuran-4-yl)acrylaldehyde 
• 1361396-61-3 (S)-dimethyl 2-(1-(2,3-dihydrobenzofuran-4-yl)-3-oxopropyl)malonate 
• 1361396-62-4 (S)-3-(2,3-dihydrobenzofuran-4-yl)-5-methoxy-4-(methoxycarbonyl)-5-oxopentanoic acid 
• 1361396-63-5 (S)-dimethyl 2-(6-oxo-2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)malonate 
• 1361396-64-6 (S)-dimethyl 2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)malonate 
• 1092507-02-2 (S)-2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)acetic acid 
• 1149757-31-2 C₁₃H₁₃ClO₂ 
• 774220-36-9 4-bromo-2,3-dihydro-1-benzofuran 
• 196597-77-0 4,5-dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one 
• 1448715-62-5 C₁₂H₁₆BrIO₃ 

196597-81-6Downstream Products

• 196597-26-9 ramelteon 
• 196597-27-0 N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide 
• 196597-16-7 N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]acetylamide 

196597-81-6Relevant articles and documents

Preparation method of ramelteon

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Paragraph 0016-0022, (2020/06/16)

The invention belongs to the field of medicinal chemistry, and mainly relates to a (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)-1-ethylamine compound represented by a formula I. The method has the advantages that the operation is simple, the steps are reduced compared with the previous method, the route is shortened, and the used solvent is single in variety, convenient to recycle and high in yield, wherein the formula I is defined in the specification.

The thunder-splitting method for amine intermediate

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Paragraph 0013; 0014; 0015; 0016; 0017; 0018, (2018/01/03)

The invention aims at providing lei meiti amine intermediate resolution method. The method of the invention to low cost optical pure chiral acid split (±) - 2 - (1, 6, 7, 8 - tetrahydro - 2 H - indenyl and [5, 4 - b] furan - 8 - yl) ethylamine preparing high optical purity of the (S)- 2 - (1, 6, 7, 8 - tetrahydro - 2 H - indenyl and [5, 4 - b] furan - 8 - yl) ethylamine. This method is simple in operation, and is suitable for industrial production.

Preparation method of high-purity ramelteon

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Paragraph 0051; 0055, (2017/08/14)

The invention discloses a preparation method of high-purity ramelteon. The preparation method comprises the following steps: taking 1,2,6,7-tetrahydro-8H-indene[5,4-b]furan-8-ketone as a starting material; carrying out reduction and amino protection through wittig-horner reaction; carrying out amino deprotection under an acidic condition; carrying out hydrogenation reaction; then carrying out chiral resolution and acrylation reaction, thus obtaining the ramelteon. The ramelteon obtained through the invention is high in product purity and higher in yield; and formation of impurities is inhibited.

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