196597-77-0

Basic information

• Product Name: 4,5-Dibromo-1,2,6,7-tertahydro-8H-indeno[5,4-b]furan-8-one
• Synonyms: 4,5-Dibromo-1,2,6,7-tertahydro-8H-indeno[5,4-b]furan-8-one;4,5-Dibromo-1,2,6,7-tertahydro-8H-indeno[5,4-β]furan-8-one;8H-Indeno[5,4-b]furan-8-one, 4,5-dibroMo-1,2,6,7-tetrahydro-;4,5-Dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one;4,5-DibroMo-6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-one;4,5-dibromo-1,2,6,7-tetrahydroindeno[5,4-b]furan-8-one
• CAS NO: 196597-77-0
• Molecular Formula: C₁₁H₈Br₂O₂
• Molecular Weight: 331.99
• Product Categories: Aromatics Compounds;Aromatics;Heterocycles
• Mol File: 196597-77-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 224-2260C
• Boiling Point: 448.593°C at 760 mmHg
• Flash Point: 225.101°C
• Appearance: /
• Density: 1.981±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Methanol
• CAS DataBase Reference: 4,5-Dibromo-1,2,6,7-tertahydro-8H-indeno[5,4-b]furan-8-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Dibromo-1,2,6,7-tertahydro-8H-indeno[5,4-b]furan-8-one(196597-77-0)
• EPA Substance Registry System: 4,5-Dibromo-1,2,6,7-tertahydro-8H-indeno[5,4-b]furan-8-one(196597-77-0)

Safety Data

• Hazardous Substances Data: 196597-77-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 196597-77-0 differently. You can refer to the following data:
1. A tricyclic indan derivative as receptor agonist; a therapeutic agent for sleep disorders
2. A tricyclic indan derivative as receptor agonist; a therapeutic agent for sleep disorders.

InChI:InChI=1/C11H8Br2O2/c12-9-5-1-2-7(14)8(5)6-3-4-15-11(6)10(9)13/h1-4H2

Upstream product

• 215057-28-6 3-(2,3-dihydro-1-benzofuran-5-yl)propanoic acid 
• 217483-05-1 ethyl 3-(2,3-dihydrobenzofuran-5-yl)acrylate 
• 198707-57-2 3-(2,3-dihydro-1-benzofuran-5-yl)prop-2-enoic acid 
• 196597-76-9 ethyl 3-(6,7-dibromo-2,3-dihydrobenzofuran-5-yl) propionic acid 
• 95-50-1 1,2-dichloro-benzene 
• 196597-67-8 ethyl 3-(7-bromo-2,3-dihydro-1-benzofuran-5-yl)propanoate 
• 196597-66-7 ethyl 3-(2,3-dihydro-1-benzofuran-5-yl)propanoate 
• 196597-65-6 ethyl (E)-3-(2,3-dihydrobenzofuran-5-yl)-2-propenoate 
• 55745-70-5 2,3-dihydro-benzofuran-5-carbaldehyde 
• 496-16-2 2.3-dihydrobenzofuran 
• 227179-21-7 3-(6,7-dibromo-2,3-dihydro-benzofuran-5-yl)-propionyl chloride 
• 196597-75-8 ethyl 3-(6,7-dibromo-2,3-dihydro-1-benzofuran-5-yl)propanoate 

Downstream Products

• 196597-78-1 1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one 
• 448964-37-2 2?(1,6,7,8?tetrahydro?2H?indeno[5,4?b]furan?8?yl)?1?ethylamine 
• 196597-79-2 (E)-2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile 
• 196597-16-7 N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]acetylamide 
• 196597-27-0 N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide 
• 1092507-06-6 C₁₁H₁₂O 
• 1092507-07-7 2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-ol 
• 196597-16-7 ramelteon 
• 196597-81-6 (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)-ethylamine 
• 221530-44-5 2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile 
• 196597-26-9 ramelteon 

Relevant articles and documents

Preparation method of ramelteon impurity

The invention relates to a preparation method of a ramelteon impurity, and belongs to the technical field of chemical synthesis. The preparation method comprises the following steps: (1) reacting a compound I with oxalyl chloride to generate an acyl chloride compound, adding aluminum trichloride, and carrying out a Friedel-Crafts reaction to generate a compound II; and (2) directionally generatinga compound III from the compound II under the action of Raney cobalt and hydrazine hydrate. The preparation method provides a novel and safe reduction condition for direct synthesis of the monosubstituted impurity, and the product does can be directly used as an impurity reference substance without purification, and also can be directly subjected to a subsequent impurity transfer experiment.

PROCESS FOR PREPARATION OF (S)-N-[2-(1,6,7,8-TETRAHYDRO-2H-INDENO[5,4-B]FURAN-8-YL)ETHYL] PROPIONAMIDE AND NOVEL INTERMEDIATES THEREOF

Disclosed herein process for preparation of (S)-Ramelteon and intermediates thereof.

PROCESS FOR THE SYNTHESIS OF RAMELTEON AND ITS INTERMEDIATES

The present invention provides processes and intermediates for the synthesis of ramelteon.