19801-37-7

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• Basic information

  1. Product Name: 6-Oxo-1,2,3,4-tetrahydro-6H-pyrimido(2,1-b)quinazoline
  2. Synonyms: 6-Oxo-1,2,3,4-tetrahydro-6H-pyrimido(2,1-b)quinazoline
  3. CAS NO:19801-37-7
  4. Molecular Formula: C₁₁H₁₁N₃O
  5. Molecular Weight: 201.23
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 19801-37-7.mol
  9. Article Data: 10

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 363.1°Cat760mmHg
  3. Flash Point: 173.4°C
  4. Appearance: /
  5. Density: 1.42g/cm³
  6. Vapor Pressure: 1.85E-05mmHg at 25°C
  7. Refractive Index: 1.729
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. CAS DataBase Reference: 6-Oxo-1,2,3,4-tetrahydro-6H-pyrimido(2,1-b)quinazoline(CAS DataBase Reference)
  11. NIST Chemistry Reference: 6-Oxo-1,2,3,4-tetrahydro-6H-pyrimido(2,1-b)quinazoline(19801-37-7)
  12. EPA Substance Registry System: 6-Oxo-1,2,3,4-tetrahydro-6H-pyrimido(2,1-b)quinazoline(19801-37-7)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 19801-37-7(Hazardous Substances Data)

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• 6H-Pyrimido[2,1-b]quinazolin-6-one,2,3,4,11-tetrahydro-

  Cas No: 19801-37-7

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• Hangzhou J&H Chemical Co., Ltd.
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• 6-Oxo-1,2,3,4-tetrahydro-6H-pyrimido(2,1-b)quinazoline

  Cas No: 19801-37-7

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19801-37-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 19801-37-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,8,0 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 19801-37:
(7*1)+(6*9)+(5*8)+(4*0)+(3*1)+(2*3)+(1*7)=117
117 % 10 = 7
So 19801-37-7 is a valid CAS Registry Number.

InChI:InChI=1/C11H11N3O/c15-10-8-4-1-2-5-9(8)13-11-12-6-3-7-14(10)11/h1-2,4-5H,3,6-7H2,(H,12,13)

19801-37-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name	2,3,4,11-tetrahydropyrimido[2,1-b]quinazolin-6-one

1.2 Other means of identification

Product number	-
Other names	1,2,3,4-tetrahydro-1,4a,9-triazaanthracen-10-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19801-37-7 SDS

19801-37-7Upstream product

• 109-76-2 Trimethylenediamine 
• 13906-05-3 3-benzyl-2-thioxo-1,2-dihydro-4(3H)-quinazolinone 
• 118-92-3 anthranilic acid 
• 109224-59-1 4,5,6,8-tetrahydro-8-oxoquinazolino<3,2,1-hi><1,3,8>triazaindolizinium chloride 
• 109192-43-0 4-(3-Chloro-propyl)-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-one 
• 92221-89-1 <1,2,4>triazolo<4,3-a>quinazolin-5-one 
• 59342-31-3 2-hydrazineylquinazolin-4(3H)-one 
• 109224-61-5 3,4,6,11-tetrahydro-6-oxo-2H-pyrimido<2,1-b>quinazoline-1-carbonitrile 
• 20112-81-6 2-(methylthio)-1,4,5,6-tetrahydropyrimidine 
• 118-48-9 isatoic anhydride 
• 552-89-6 2-nitro-benzaldehyde 
• 1361234-74-3 2-amino-3-(3-aminopropyl)quinazolin-4(3H)-one 
• 342625-96-1 3,4-dihydro-2H,6H-pyrimido[1,2-c]quinazolin-6-amine 
• 1361234-34-5 methyl N-cyano-2-nitrobenzenecarboximidoate 

19801-37-7Downstream Products

• 160776-57-8 1-ethoxycarbonylmethyl-6-oxo-1,2,3,4-tetrahydro-6H-pyrimido<2,1-b>quinazoline 

19801-37-7Relevant articles and documents

Structures of 1,2,3,4-tetrahydro-6H-pyrimidoquinazolin-6-one and its hydrochloride

Glowka, Marek L.,Olczak, Andrzej,Korzycka, Lucyna

, p. 725 - 730 (1994)

C11H11N3O, m.p. 243 deg C, P2/n, Z = 4, a = 5.843(2), b = 14.241(3), c = 11.102(1) Angstroem, β = 93.30(2) deg, R = 0.046; C11H11N3O*HCl*H2O, Pca21, Z = 8, a = 18.640(2), b = 8.894(2), c = 14.404(2) Angstroem, R = 0.062.The molecules of the free base are in 1H-tautomeric form.N(1)-H...N(11) hydrogen bonds join molecules of the free base into dimers, which enable tautomeric rearrangement (not observed in this study) also in the solid state without any changes in molecular packing.The quinazoline system deviates slightly from planarity and benzene ? electrons are partially localized at C(7)-C(8) and C(9)-C(10) bonds as seen from their lengths of about 1.375 Angstroem, while other bonds in the benzene ring are at least 0.02 Angstroem longer.Key words: Pyrimidoquinazoline, hydrochloride, neuroleptic.

Divergent 2-Chloroquinazolin-4(3H)-one Rearrangement: Twisted-Cyclic Guanidine Formation or Ring-Fused N-Acylguanidines via a Domino Process

Yan, Gang,Zekarias, Bereket L.,Li, Xiaoyu,Jaffett, Victor A.,Guzei, Ilia A.,Golden, Jennifer E.

, p. 2486 - 2492 (2020/02/13)

A highly efficient 2-chloroquinazolin-4(3H)-one rearrangement was developed that predictably generates either twisted-cyclic or ring-fused guanidines in a single operation, depending on the presence of a primary versus secondary amine in the accompanying diamine reagent. Exclusive formation of twisted-cyclic guanidines results from pairing 2-chloroquinazolinones with secondary diamines. Use of primary amine-containing diamines permits a domino quinazolinone rearrangement/intramolecular cyclization, gated through (E)-twisted-cyclic guanidines, to afford ring-fused N-acylguanidines. This scalable, structurally tolerant transformation generated 55 guanidines and delivered twisted-cyclic guanidines with robust plasma stability and an abbreviated total synthesis of an antitumor ring-fused guanidine (4 steps, 55 % yield).

Radical synthesis of guanidines from N-Acyl cyanamides

Larraufie, Marie-Helene,Ollivier, Cyril,Fensterbank, Louis,Malacria, Max,Lacote, Emmanuel

supporting information; experimental part, p. 2178 - 2181 (2010/06/18)

Chemical Equation Presented Center stage: Additions of nitrogen-centered radicals to cyanamide compounds provided the first radical synthesis of aromatic polycyclic guanidine derivatives (see scheme). Modular assembly of the substrates allows for a rapid increase of the molecular complexity of scaffolds, which have potential applications for medicinal chemistry.

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