19881-70-0 Usage
Uses
Windorphen is a selective inhibitor of p300 histone acetyltransferase, a coactivator that associates with?β-catenin,?blocking the Wnt signal required for ventral development.
Biological Activity
windorphen is a wnt inhibitor that selectively abrogates the wnt signaling for ventral development.wnt protein is a family of signaling proteins that interacts on the wnt/β-catenin pathways during embryotic development, cell proliferation, migration and adult tissue homeostasis.in canonical wnt/β-catenin reporter cell line stf293, windorphen dose-dependently inhibits wnt3a-inducible topflash-luciferase activity (ic50 of 1.5 mm). in human colon adenocarcinomasw480 cells with defective apc gene that constitutively activates wnt signaling, 72 h treatment of windorphen causes a wide spread apoptosis. [1]in zebrafish embryos, windorphen leads to apparent expansion of the dorsal markers (pax2.1) and marker of rhombomeres 3 and 5 at the six-somite stage (krox0). windorphen selectively inhibits wnt signaling in ventral and lateral regions of the 50% epiboly stage embryo (5.3 hpf). in addition, windoprhen treatment rescues the telencephalon/eye phenotype in the mbl mutant zebrafish (i.e. a defective axin1/β-catenin destruction complex causes abnormal activation of wnt signaling and the loss of telencephalon and eyes.) [1]
references
1. hao j, ao a, zhou l et al. selective small molecule targeting β-catenin function discovered by invivo chemical genetic screen. cell rep. 2013 sep 12;4(5):898-904.
Check Digit Verification of cas no
The CAS Registry Mumber 19881-70-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,8,8 and 1 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 19881-70:
(7*1)+(6*9)+(5*8)+(4*8)+(3*1)+(2*7)+(1*0)=150
150 % 10 = 0
So 19881-70-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H15ClO3/c1-20-14-7-3-12(4-8-14)16(11-19)17(18)13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b17-16-
19881-70-0Relevant articles and documents
Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles
Scholz, Michael,Ulbrich, Holger K.,Dannhardt, Gerd
, p. 1152 - 1159 (2008/09/20)
The aim of this study was to investigate 4,5-diaryl isoselenazoles as multiple target non-steroidal anti-inflammatory drugs (MTNSAIDs) which can intervene into the inflammatory processes via different mechanisms of action creating a new class of compounds
Cytotoxicity of substituted alkyl-3,4-bis(4-methoxyphenyl)pyrrole-2- carboxylates in L1210 lymphoid leukemia cells
Burnham,Gupton,Krumpe,Webb,Shuford,Bowers,Warren,Barnes,Hall
, p. 337 - 341 (2007/10/03)
Two alkyl-3,4-bis(4-methoxyphenyl)pyrrole-2-carboxylates proved to be potent cytotoxic agents in the murine L1210 lymphoid leukemia screen. DNA synthesis was preferentially inhibited with the major target of the agents being de novo purine biosynthesis at the regulatory enzyme sites of PRPP- amido transferase and IMP dehydrogenase. Other enzymatic activities which were suppressed by the drugs were DNA polymerase α, RNA polymerases, ribonucleoside reductase and dihydrofolate reductase. The d[NTP] pools, nucleoside kinase and the pyrimidine pathway were not affected by the presence of drugs. The DNA molecule itself was not the target of the agents, i.e. no alkylation of nucleotide bases, intercalation between bases or cross- linking of DNA strands occurred. The agents did cause L1210 DNA fragmentation after 24 h incubation at 100 μM.
