66521-59-3

Basic information

• Product Name: 3-(DIMETHYLAMINO)-1,2-BIS(4-METHOXYPHENYL)-2-PROPEN-1-ONE
• Synonyms: 3-(DIMETHYLAMINO)-1,2-BIS(4-METHOXYPHENYL)-2-PROPEN-1-ONE
• CAS NO: 66521-59-3
• Molecular Formula: C₁₉H₂₁NO₃
• Molecular Weight: 311.37
• Mol File: 66521-59-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 119-121°C
• Boiling Point: 472.2°C at 760 mmHg
• Flash Point: 239.4°C
• Appearance: /
• Density: 1.106g/cm³
• Vapor Pressure: 4.35E-09mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 3-(DIMETHYLAMINO)-1,2-BIS(4-METHOXYPHENYL)-2-PROPEN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(DIMETHYLAMINO)-1,2-BIS(4-METHOXYPHENYL)-2-PROPEN-1-ONE(66521-59-3)
• EPA Substance Registry System: 3-(DIMETHYLAMINO)-1,2-BIS(4-METHOXYPHENYL)-2-PROPEN-1-ONE(66521-59-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 66521-59-3(Hazardous Substances Data)

Usage

General Description

3-(Dimethylamino)-1,2-bis(4-methoxyphenyl)-2-propen-1-one is a complex organic compound comprised of a central 2-propen-1-one structure modified by a dimethylamino group and two 4-methoxyphenyl groups. The presence of these functional groups significantly influences its properties. The compound is characteristically aromatic due to the phenyl groups and the methoxy groups contribute to its solubility in organic solvents. The dimethylamino group adds basic functionality, making the chemical potentially reactive with acids. Additionally, the propenone backbone of the compound is a known Michael acceptor, enabling it to participate in Michael addition reactions that are widely used in organic synthesis. 3-(DIMETHYLAMINO)-1,2-BIS(4-METHOXYPHENYL)-2-PROPEN-1-ONE's unique structure and properties could make it useful in various fields, such as materials science, pharmaceuticals, or polymers.

InChI:InChI=1/C19H21NO3/c1-20(2)13-18(14-5-9-16(22-3)10-6-14)19(21)15-7-11-17(23-4)12-8-15/h5-13H,1-4H3/b18-13+

Upstream product

• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 5815-08-7 tert-Butoxybis(dimethylamino)methane 

Downstream Products

• 141424-86-4 4,5-Bis-(4-methoxy-phenyl)-pyrimidin-2-yl-cyanamide 
• 39831-04-4 1-(4-methoxyphenyl)-1-chloro-2-(4-methoxyphenyl)-2-formylethylene 
• 2810-91-5 2,3-bis-(4-methoxy-phenyl)-6-nitro-quinoxaline 
• 1226-42-2 1,2-bis(4-methoxyphenyl)-1,2-ethanedione 
• 84831-83-4 4,5-Bis-(4-methoxyphenyl)-2-(4-fluorphenylthio)pyrimidin 
• 84831-82-3 4,5-Bis-(4-methoxyphenyl)-2-phenylthiopyrimidin 
• 84831-84-5 4,5-Bis-(4-methoxyphenyl)-2-(2-thienylthio)pyrimidin 
• 141424-92-2 2-[1-(3-Fluoro-benzyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-4,5-bis-(4-methoxy-phenyl)-pyrimidine 

Relevant articles and documents

Further studies on the application of vinylogous amides and β-halovinylaldehydes to the regiospecific synthesis of unsymmetrical, polyfunctionalized 2,3,4- and 1,2,3,4- substituted pyrroles

Highly functionalized pyrroles with appropriate regiochemical functionality represent an important class of marine natural products and potential drug candidates. We describe herein a detailed study of the reaction of α-aminoacid esters with vinylogous amides and also β-halovinylaldehydes for the regiospecific synthesis of 2,3,4-trisubstituted and 1,2,3,4-tetrasubstituted pyrroles. Since the vinylogous amides and β-halovinylaldehydes are readily available precursors, rapid access to a wide variety of unsymmetrically substituted pyrroles is accomplished via this methodology.

Studies on anti-platelet agents. IV. A series of 2-substituted 4,5-bis(4-methoxyphenyl)pyrimidines as novel anti-platelet agents

The syntheses and structure-activity relationships of a series of 2-substituted 4,5-bis(4-methoxyphenyl)pyrimidines, designed on the basis of structural analyses of several cyclooxygenase (CO) inhibitors, and their derivatives as anti-platelet agents base