39905-57-2Relevant articles and documents
PHOTORESPONSIVE COMPOUND, AND ADHESIVE, TONER AND IMAGE FORMATION METHOD USING THE SAME
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Paragraph 0214; 0217-0218, (2021/05/07)
PROBLEM TO BE SOLVED: To provide a compound that is fluidized by light irradiation and is un-fluidized reversibly, and shows no excessive coloration. SOLUTION: The present invention relates to a compound of chemical formula 1a or 1b: R1 and r1 each denote a hydrogen atom, a halogen atom or the like; R2-R7 and r2-r7 each denote a group represented by chemical formula 2, a hydrogen atom, a halogen atom or the like, where at least one of R2-R7 and r2-r7 is a group represented by chemical formula 2; in chemical formula 2, X1 and X2 each denote N or CH, and X1≠X2; A1-A5 each denote a hydrogen atom, a halogen atom or the like, where at least one of A1-A5 is an alkyl group, an alkoxy group, an acyl group, an alkoxycarbonyl group, or an acyloxy group. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
Discovery of Diphenoxy Derivatives with Flexible Linkers as Ligands for β-Amyloid Plaques
Jia, Jianhua,Zhang, Longfei,Song, Jia,Dai, Jiapei,Cui, Mengchao
, p. 4089 - 4100 (2020/12/13)
The highly rigid and planar scaffolds with π-conjugated systems have been widely considered to be indispensable for β-amyloid (Aβ) binding ligands. In this study, a library of diphenoxy compounds with different types of more flexible linkers as Aβ ligands were synthesized and evaluated. Most of them displayed good affinity (Ki1-42aggregates, and some ligands even showed values of Kiless than 10 nM. Structure-activity relationship analysis revealed that modification on the linkers or substituents tolerated great flexibility, which challenged the long-held belief that rigid and planar structures are exclusively favored for Aβ binding. Three ligands were labeled by iodine-125, and they exhibited good properties in vitro and in vivo, which further supported that this flexible scaffold was potential and promising for the development of Aβ imaging agents.
Synthesis, liquid crystalline properties and photo switching properties of coumarin-azo bearing aliphatic chains: Application in optical storage devices
Madiahlagan, Eswaran,B N, Sunil,Ngaini, Zainab,Hegde, Gurumurthy
, (2019/07/31)
A series of novel azo-coumarin derivatives with different aliphatic chain length (3a-e) have been synthesized and characterized for liquid crystal properties and their photoswitching behavior. The incorporation of coumarin along with azobenzene was prepared via esterification reaction and differ in the length of alkyl group, CnH2n+1, where n = 6, 8, 10, 12 and 14. Azo-coumarin bearing C14 alkyl chain shows Smectic–A phase while azo-coumarin bearing rest of long alkyl chain exhibited Nematic phase. The incorporation of natural product moieties into azobenzene network has increased electron delocalisation and liquid crystal properties. The photoswitching properties of said molecules were tested and the coumarin-azo compounds 3a-e took ~46 s to reach photostationary state during UV illumination and exhibited long thermal back relaxation time (~16 h) in solutions. Device is also fabricated to see the performance of the device with respect to the alkyl chain length. Presented studies show the importance of azo-coumarin derivatives with different chain length for the application of optical storage devices.
